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Titolo:
HEPATIC OVEREXPRESSION OF BOVINE SCAVENGER RECEPTOR-TYPE-I IN TRANSGENIC MICE PREVENTS DIET-INDUCED HYPERBETALIPOPROTEINEMIA
Autore:
WOLLE S; VIA DP; CHAN L; CORNICELLI JA; BISGAIER CL;
Indirizzi:
PARKE DAVIS PHARMACEUT RES,DEPT ATHEROSCLEROSIS THERAPEUT,2800 PLYMOUTH RD ANN ARBOR MI 48105 PARKE DAVIS PHARMACEUT RES,DEPT ATHEROSCLEROSIS THERAPEUT ANN ARBOR MI 48105 BAYLOR COLL MED,DEPT MED HOUSTON TX 77030 BAYLOR COLL MED,DEPT CELL BIOL HOUSTON TX 77030 BAYLOR COLL MED,METHODIST HOSP HOUSTON TX 77030
Titolo Testata:
The Journal of clinical investigation
fascicolo: 1, volume: 96, anno: 1995,
pagine: 260 - 272
SICI:
0021-9738(1995)96:1<260:HOOBSR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE CELLS; HUMAN MONOCYTE-MACROPHAGES; ALDEHYDE-MODIFIED PROTEINS; ENDOTHELIAL-CELLS; RAT-LIVER; CHOLESTEROL DEPOSITION; MEDIATED RECOGNITION; SERUM-ALBUMIN; ATHEROSCLEROSIS;
Keywords:
MINIGENE; LIPOPROTEIN PROFILE; TRANSGENIC MICE; HEPATIC LIPIDS; APO-B CONTAINING LIPOPROTEIN HDL RATIO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
89
Recensione:
Indirizzi per estratti:
Citazione:
S. Wolle et al., "HEPATIC OVEREXPRESSION OF BOVINE SCAVENGER RECEPTOR-TYPE-I IN TRANSGENIC MICE PREVENTS DIET-INDUCED HYPERBETALIPOPROTEINEMIA", The Journal of clinical investigation, 96(1), 1995, pp. 260-272

Abstract

Hepatic scavenger receptors (SR) may play a protective role by clearing modified lipoproteins before they target the artery wall. To gain insight into this hypothesized function, transgenic mice expressing hepatic bovine SR (TgSR) were created and studied when fed chow, and during diet-induced hyperlipidemia. SR overexpression resulted in extensive hepatic parenchymal cell uptake of fluorescently labeled acetylated human low density lipoprotein (DiI ac-hLDL) and a twofold increase in I-125-acetylated-LDL clearance. Food intake and cholesterol absorptionwas indistinguishable between control and TgSR mice. In chow-fed mice, lipoprotein cholesterol was similar in control and TgSR mice. However, on a 3-wk high fat/cholesterol (HFHC) diet, the rise in apoB containing lipoproteins was suppressed in TgSR+/- and TgSR+/+ mice. The risein HDL was similar in control and TgSR+/- mice, but significantly elevated in the TgSR+/+ mice. Overall, on chow, the ratio of apo-B containing lipoprotein cholesterol to HDL cholesterol was similar for all groups (control = 0.33; TgSR+/- = 0.32; TgSR+/+ = 0.38). However, after 3 wk on the HFHC diet, this ratio was markedly higher in control (2.34-/-0.21) than in either TgSR+/- (1.00+/-0.24) or TgSR+/+ (1.00+/-0.19)mice. In TgSR+/- mice, hepatic cholesteryl esters were reduced by 59%, 7 alpha-hydroxylase mRNA levels were elevated twofold, and a significant increase in fecal bile add flux was observed after the 3-wk HFHC diet. These results suggest SR may play a protective role in liver by preventing diet-induced increases in apoB containing lipoproteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 09:19:08