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Titolo:
EVIDENCE OF A DIRECT ROLE FOR GROWTH-HORMONE (GH) IN MAMMARY-GLAND PROLIFERATION AND LACTATION
Autore:
LINCOLN DT; SINOWATZ F; ELHIFNAWI E; HUGHES RL; WATERS M;
Indirizzi:
UNIV KUWAIT,FAC ALLIED HLTH SCI,DEPT MED LAB TECHNOL,POB 31470 SULIBIKHAT 90805 KUWAIT INDEPENDENT RES FDN CHAPEL HILL AUSTRALIA UNIV MUNICH,INST VET ANAT 2 MUNICH GERMANY UNIV LUBECK,DEPT OPHTHALMOL W-2400 LUBECK GERMANY UNIV QUEENSLAND,DEPT PHYSIOL ST LUCIA QLD AUSTRALIA UNIV QUEENSLAND,DEPT ANAT SCI ST LUCIA QLD AUSTRALIA
Titolo Testata:
Anatomia, histologia, embryologia
fascicolo: 2, volume: 24, anno: 1995,
pagine: 107 - 115
SICI:
0340-2096(1995)24:2<107:EOADRF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
D.T. Lincoln et al., "EVIDENCE OF A DIRECT ROLE FOR GROWTH-HORMONE (GH) IN MAMMARY-GLAND PROLIFERATION AND LACTATION", ANAT HISTOL, 24(2), 1995, pp. 107-115

Abstract

A panel of monoclonal antibodies to the growth hormone (GH) receptor/binding protein was used to demonstrate the existence and detail the expression of GH receptors in ductal and alveolar epithelial cells fromrat and rabbit mammary glands by immunohistochemistry. Intense immunoreactivity was present in membrane, cytoplasm and some nuclei of epithelial cells during proliferation and lactation. Receptor expression decreased during weaning and was absent or weak in regressive mammary glands. Immunoreactivity was weak in ductal epithelial cells from virginadult animals. Pronounced expression of GH receptor/binding protein was observed with two monoclonal antibodies and lesser reactivity was seen with others, paralleling their affinities for the receptor. The cytoplasmic presence of this putatively plasma membrane located GH receptor is accounted for by the existence of a soluble form on the GH receptor, namely the growth hormone binding protein derived from the membrane receptor by cleavage. Primary localization of the receptor in proliferating and lactating epithelial cells suggests that the rat and rabbit mammary gland is a GH target tissue. This finding is in contradiction to both classical GH action and the somatomedin hypothesis and challenges the widely held view that GH has no direct influence on mammary growth and function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:36:06