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Titolo:
BETA-CIT SPECT DEMONSTRATES BLOCKADE OF 5HT-UPTAKE SITES BY CITALOPRAM IN THE HUMAN BRAIN IN-VIVO
Autore:
PIRKER W; ASENBAUM S; KASPER S; WALTER H; ANGELBERGER P; KOCH G; POZZERA A; DEECKE L; PODREKA I; BRUCKE T;
Indirizzi:
UNIV VIENNA,NEUROL KLIN,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,NEUROL KLIN A-1090 VIENNA AUSTRIA UNIV VIENNA,PSYCHIAT CLIN A-1090 VIENNA AUSTRIA UNIV VIENNA,NUCL MED CLIN A-1090 VIENNA AUSTRIA FORSCHUNGSZENTRUM SEIBERSDORF SEIBERSDORF AUSTRIA
Titolo Testata:
Journal of neural transmission
fascicolo: 3, volume: 100, anno: 1995,
pagine: 247 - 256
SICI:
0300-9564(1995)100:3<247:BSDBO5>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIDEPRESSANT BINDING-SITES; H-3 PAROXETINE; SEROTONIN TRANSPORTERS; REUPTAKE SITES; DOPAMINE; 2-BETA-CARBOMETHOXY-3-BETA-(4-IODOPHENYL)TROPANE; LOCALIZATION;
Keywords:
ANTIDEPRESSANTS; BETA-CIT; CITALOPRAM; DEPRESSION; DOPAMINE REUPTAKE; SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS); SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
W. Pirker et al., "BETA-CIT SPECT DEMONSTRATES BLOCKADE OF 5HT-UPTAKE SITES BY CITALOPRAM IN THE HUMAN BRAIN IN-VIVO", Journal of neural transmission, 100(3), 1995, pp. 247-256

Abstract

The cocaine analogue 2-beta-carbomethoxy-3-beta-(4-iodophenyl)-tropane (beta-CIT) is a potent ligand for both dopamine- and serotonin uptake sites which in its I-123 labeled form can be used for single photon emission computerized tomography (SPECT). It was demonstrated previously by SPECT-studies in non-human primates that I-123-beta-CIT binds todopamine transporters in the striatum and to serotonin transporters in hypothalamus and midbrain. The aim of the present study was to compare I-123-beta-CIT binding in the brain stem of normal controls and a group of subjects under treatment with the selective serotonin reuptakeinhibitor (SSRI) citalopram. T-123-beta-CIT-SPECT was performed in 12depressed patients under 20 mg (n = 5), 40 mg (n = 6) and 60 mg (n = 1) citalopram daily, in one untreated depressed patient and in 11 controls at regular time intervals up till 24 hours p.inj. A highly significant reduction of beta-CIT binding was found in an area including mesial thalamus, hypothalamus, midbrain and pens in patients under citalopram compared to controls (44.1 +/- 14.4 vs. 82.3 +/- 18.6 cpm's/mCi xkg body weight; specific binding 4 hrs p.inj.; p = 0.0001). No differences were seen between the high and low dose group and no changes were found in the striatum. I-123-beta-CIT binding in the brain stem and striatum in one untreated depressed patient fell within the range of control values. To our knowledge this is the first report directly demonstrating the effect of a selective serotonin uptake inhibitor in the brain in humans in vivo. SPECT measurements of serotonin uptake sites in patients with depression and other psychiatric disorders might provide better insights into the pathophysiology of these disorders and into mechanisms of drug action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:54:23