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Titolo:
SPHINGOMYELIN-CERAMIDE TURNOVER IN CD28 COSTIMULATORY SIGNALING
Autore:
CHAN G; OCHI A;
Indirizzi:
JOHN P ROBARTS RES INST,AUTOIMMUN GRP,1400 WESTERN RD LONDON ON N6G 2V4 CANADA JOHN P ROBARTS RES INST,AUTOIMMUN GRP LONDON ON N6G 2V4 CANADA
Titolo Testata:
European Journal of Immunology
fascicolo: 7, volume: 25, anno: 1995,
pagine: 1999 - 2004
SICI:
0014-2980(1995)25:7<1999:STICCS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; T-CELL ACTIVATION; NF-KAPPA-B; FACTOR-ALPHA; PROTEIN-KINASE; LYMPHOCYTES-T; HL-60 CELLS; FREE SYSTEM; ANTIGEN; RECEPTOR;
Keywords:
SPHINGOMYELIN; CERAMIDE; CD28;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
G. Chan e A. Ochi, "SPHINGOMYELIN-CERAMIDE TURNOVER IN CD28 COSTIMULATORY SIGNALING", European Journal of Immunology, 25(7), 1995, pp. 1999-2004

Abstract

When the CD28 membrane glycoprotein of T cells binds to its ligand, asignal is transmitted that is required for T cell receptor-induced proliferation and cytokine secretion; T cells are not stimulated by the CD28 signal alone. Ligation of CD28 initiated sphingomyelin hydrolysisand generated ceramide. Treatment of T cells with either exogenous sphingomyelinase or a cell-permeable ceramide analogue, CB-ceramide, mimicked the CD28 signal by inducing T cell proliferation and interleukin-2 gene transcription. Stabilization of interleukin-2 mRNA was also observed in C-6-ceramide-treated cells. Thus, the sphingomyelin-ceramidepathway is a candidate for mediating the costimulatory signal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 17:26:53