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Titolo:
PREVENTION AND TREATMENT OF LEWIS RAT EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS WITH A MONOCLONAL-ANTIBODY TO THE T-CELL RECEPTOR V-BETA-8.2 SEGMENT
Autore:
IMRICH H; KUGLER C; TORRESNAGEL N; DORRIES R; HUNIG T;
Indirizzi:
UNIV WURZBURG,INST VIROL & IMMUNBIOL,VERBACHER STR 7 D-97078 WURZBURGGERMANY UNIV WURZBURG,INST VIROL & IMMUNBIOL D-97078 WURZBURG GERMANY
Titolo Testata:
European Journal of Immunology
fascicolo: 7, volume: 25, anno: 1995,
pagine: 1960 - 1964
SICI:
0014-2980(1995)25:7<1960:PATOLR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; MEDIATING AUTOIMMUNE ENCEPHALOMYELITIS; REGION DISEASE HYPOTHESIS; CENTRAL-NERVOUS-SYSTEM; BETA-CHAIN USAGE; LYMPHOCYTE-T; MULTIPLE-SCLEROSIS; ANTIGEN RECEPTOR; DETERMINANT; THERAPY;
Keywords:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MONOCLONAL ANTIBODY THERAPY; T CELL RECEPTOR V-BETA-8.2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
H. Imrich et al., "PREVENTION AND TREATMENT OF LEWIS RAT EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS WITH A MONOCLONAL-ANTIBODY TO THE T-CELL RECEPTOR V-BETA-8.2 SEGMENT", European Journal of Immunology, 25(7), 1995, pp. 1960-1964

Abstract

The predominance of T cell receptor (TCR) V beta 8.2 utilization by encephalitogenic T cells induced in Lewis rats by immunization with myelin basic protein (MBP) is controversial. Thus, both an almost exclusive usage of V beta 8.2 [Burns, ER., Li, X., Shen, N., Offner, H., Chou, Y. K., Vandenbark, A. A. and Heber-Katz, E., J. Exp. Med. 1989. 169:27; Chluba, J., Steeg, C., Becker, A., Wekerle, H. and Epplen, J. T.,fur. J. Immunol. 1989. 19: 279] and a quite diverse V beta composition of CD4 T cells causing experimental autoimmune encephalomyelitis (EAE) [Sun, D., Gold, P. D., Smith, L., Brostoff, S. and Cole dough, C., Eur. J. Immunol. 1992. 22: 591; Sun, D., Le, J. and Coleclough, C., Eur. J. Immunol. 1993. 23: 494] have been reported. Using a recently developed monoclonal antibody (mAb) specific for TCR V beta 8.2, we show that postnatal treatment effectively eliminates V beta 8.2-bearing cells and prevents MBP-induced EAE in the majority of Lewis rats. Moreover, treatment of adult Lewis rats with V beta 8.2-specific mAb as late as on day 12 after MBP immunization suppressed the development of neurological symptoms. Thus, V beta 8.2-bearing cells do play a decisive role in Lewis rat EAE, and suppression of the small (5%) V beta 8.2-expressing T cell subset provides an effective therapeutic strategy.

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Documento generato il 01/12/20 alle ore 16:45:23