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Titolo:
INTRA-THYMIC AND EXTRA-THYMIC EXPRESSION OF THE PRE-T CELL-RECEPTOR ALPHA-GENE
Autore:
BRUNO L; ROCHA B; ROLINK A; VONBOEHMER H; RODEWALD HR;
Indirizzi:
BASEL INST IMMUNOL,GRENZACHERSTR 487 CH-4005 BASEL SWITZERLAND INST NECKER,INSERM,U345 PARIS FRANCE
Titolo Testata:
European Journal of Immunology
fascicolo: 7, volume: 25, anno: 1995,
pagine: 1877 - 1882
SICI:
0014-2980(1995)25:7<1877:IAEEOT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSGENIC MICE; MONOCLONAL-ANTIBODY; ANTIGEN RECEPTOR; BETA-CHAIN; POSITIVE SELECTION; CD4+8+ THYMOCYTES; DEFICIENT MICE; TCR-BETA; DIFFERENTIATION; IMMATURE;
Keywords:
PRE-T CELL RECEPTOR ALPHA; THYMIC DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
L. Bruno et al., "INTRA-THYMIC AND EXTRA-THYMIC EXPRESSION OF THE PRE-T CELL-RECEPTOR ALPHA-GENE", European Journal of Immunology, 25(7), 1995, pp. 1877-1882

Abstract

We have analyzed pre-T cell receptor alpha(pT alpha) gene expression in cells from various anatomical sites to investigate the lineage specificity of pT alpha RNA as well as its presence in pro-T cells and in sites of extrathymic T cell development. pT alpha RNA is found in precursors of alpha beta T cells but is absent from mature alpha beta T cells as well as T cells that express the gamma delta T cell receptor onthe cell surface. pT alpha expression is exquisitely T lineage specific in that mature and immature B cells, myeloid cells, NK cells and pluripotent stem cells are pT alpha negative. On the other hand, pT alpha expression is found in pro-T cells outside the thymus as well as in intra- and extra-thymic sites of T cell development. The latter finding is consistent with the notion that early steps of T cell developmentwithin and outside the thymus may be similar.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 08:47:49