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Titolo:
LOW-INTENSITY ORAL ANTICOAGULATION IN SICKLE-CELL DISEASE REVERSES THE PRETHROMBOTIC STATE - PROMISES FOR TREATMENT
Autore:
WOLTERS HJ; TENCATE H; THOMAS LLM; BRANDJES DPM; VANDERENDE A; VANDERHEIDEN Y; VANEPS LWS;
Indirizzi:
SLOTERVAART MUNICIPAL HOSP,DEPT INTERNAL MED,LOUWESWEG 6 1066 EC AMSTERDAM NETHERLANDS SLOTERVAART MUNICIPAL HOSP,DEPT CLIN CHEM 1066 EC AMSTERDAM NETHERLANDS ACAD MED CTR,CTR THROMBOSIS HAEMOSTASIS ATHEROSCLEROSIS & INFL AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM,FAC MED,DEPT HAEMATOL AMSTERDAM NETHERLANDS DEPT GEOG PATHOL AMSTERDAM NETHERLANDS
Titolo Testata:
British Journal of Haematology
fascicolo: 3, volume: 90, anno: 1995,
pagine: 715 - 717
SICI:
0007-1048(1995)90:3<715:LOAISD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Keywords:
SICKLE-CELL DISEASE; ORAL ANTICOAGULANTS; HYPERCOAGULABILITY; THROMBIN PRODUCTION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Wolters et al., "LOW-INTENSITY ORAL ANTICOAGULATION IN SICKLE-CELL DISEASE REVERSES THE PRETHROMBOTIC STATE - PROMISES FOR TREATMENT", British Journal of Haematology, 90(3), 1995, pp. 715-717

Abstract

Increased plasma levels of prothrombin fragment 1 + 2 (F1 + 2) found in patients with sickle-cell disease reflect enhanced endogenous thrombin generation, We postulate that hypercoagulability contributes to vaso-occlusion. The intensity of acenocoumarol treatment required to reduce the F1 + 2 level to 50% of pretreatment level was investigated in seven patients with symptomatic sickle-cell anaemia during steady-state disease for a period of 2 months, All patients had increased levels of F1 + 2 compared with an age-matched control group. Normalization ofthe F1 + 2 was achieved at a median INR of 1 . 64 (range 1 . 18-2 . 2). it is concluded that low-intensity oral anticoagulation normalizes the hypercoagulability in sickle-cell disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 14:49:54