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Titolo:
CLONAL B-CELL EXPANSIONS IN PERIPHERAL-BLOOD OF HCV-INFECTED PATIENTS
Autore:
FRANZIN F; EFREMOV DG; POZZATO G; TULISSI P; BATISTA F; BURRONE OR;
Indirizzi:
INT CTR GENET ENGN & BIOTECHNOL,AREA SCI PK,PADRICIANO 99 I-34012 TRIESTE ITALY INT CTR GENET ENGN & BIOTECHNOL I-34012 TRIESTE ITALY OSPED CATTINARA TRIESTE ITALY
Titolo Testata:
British Journal of Haematology
fascicolo: 3, volume: 90, anno: 1995,
pagine: 548 - 552
SICI:
0007-1048(1995)90:3<548:CBEIPO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-C VIRUS; ESSENTIAL MIXED CRYOGLOBULINEMIA; POLYMERASE CHAIN-REACTION; MALIGNANCIES;
Keywords:
HCV; MIXED CRYOGLOBULINEMIA; IGM; B-LYMPHOCYTES; CLONAL EXPANSIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
F. Franzin et al., "CLONAL B-CELL EXPANSIONS IN PERIPHERAL-BLOOD OF HCV-INFECTED PATIENTS", British Journal of Haematology, 90(3), 1995, pp. 548-552

Abstract

Clonal expansions of IgM-producing B cells were investigated in 38 patients with a chronic hepatitis C virus infection. Eight patients wereaffected with type II mixed cryoglobulinaemia (two of whom also had non-Hodgkin's lymphoma and one had Waldenstrom's disease), one with type III mixed cryoglobulinaemia, one with Waldenstrom's disease, and 28 with chronic liver disease. To detect the clonal B-cell expansions we used a RT/PCR procedure in which the CDR3/FW4 regions of the IgM heavychain mRNAs were amplified and resolved in sequencing polyacrylamide gels. Clonal Ig gene rearrangements were detected in all patients withtype II mixed cryoglobulinaemia and also at a high frequency (24%) inthe HCV-infected patients without cryoglobulinaemia. A polyclonal pattern was present in the patient with type III mixed cryoglobulinaemia and in the 15 normal individuals and 16 age-related patients with HCV-negative alcoholic liver disease which were investigated as controls. No association was found between the presence of a clonal B-cell expansion and age, sex, liver histology, or levels of serum aminotransferase. The serum levels of rheumatoid factor were increased in all patients with a clonal expansion, suggesting that the expanded B-cell clones belong to the rheumatoid factor producing B-cell subset.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:35:58