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Titolo:
EMBRYONIC STRIATAL GRAFTS REVERSE THE DISINHIBITORY EFFECTS OF IBOTENIC ACID LESIONS OF THE VENTRAL STRIATUM
Autore:
READING PJ; DUNNETT SB;
Indirizzi:
UNIV CAMBRIDGE,MRC,CTR BRAIN REPAIR,FORVIE SITE CAMBRIDGE CB2 2PY ENGLAND UNIV CAMBRIDGE,MRC,CTR BRAIN REPAIR CAMBRIDGE CB2 2PY ENGLAND
Titolo Testata:
Experimental Brain Research
fascicolo: 1, volume: 105, anno: 1995,
pagine: 76 - 86
SICI:
0014-4819(1995)105:1<76:ESGRTD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNILATERAL NEOSTRIATAL LESIONS; NUCLEUS-ACCUMBENS-SEPTI; DIFFERENTIAL REINFORCEMENT; HUNTINGTONS-DISEASE; 6-OHDA LESIONS; RESPONSE DISINHIBITION; NIGROSTRIATAL PATHWAY; BEHAVIORAL RECOVERY; HIPPOCAMPAL-LESIONS; DOPAMINERGIC GRAFTS;
Keywords:
NEURAL TRANSPLANTATION; STRIATAL GRAFTS; VENTRAL STRIATUM; NUCLEUS ACCUMBENS; DRL SCHEDULE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Reading e S.B. Dunnett, "EMBRYONIC STRIATAL GRAFTS REVERSE THE DISINHIBITORY EFFECTS OF IBOTENIC ACID LESIONS OF THE VENTRAL STRIATUM", Experimental Brain Research, 105(1), 1995, pp. 76-86

Abstract

Bilateral damage to the ventral striatum induced by the excitotoxin ibotenic acid was found to have profound disinhibitory effects on rats'behaviour. Lesioned animals were unable to acquire efficient levels of performance on an operant schedule (differential reinforcement of low rates of responding, DRL) that required them to inhibit a previouslyrewarded response. In addition, lesioned subjects were relatively resistant to the disruptive effects of amphetamine on performance of the DRL schedule and were slower to cease responding under conditions of non-reward. A measure of unconditioned behaviour, overnight locomotor activity, was also disinhibited by the presence of the lesion. Grafts of embryonic striatal tissue transplanted to the lesioned ventral striatum were found to survive well. Moreover, the presence of the grafts reversed the effects of the lesion on measures of conditioned and unconditioned behaviour. The nature of the lesion-induced behavioural deficit and the ability of the embryonic transplants to reverse it are discussed in terms of the possible restoration of limbic-subcortical circuitry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:53:58