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Titolo:
SUSCEPTIBILITY OF UGANDAN TRYPANOSOMA-BRUCEI-RHODESIENSE ISOLATED FROM MAN AND ANIMAL RESERVOIRS TO DIMINAZENE, ISOMETAMIDIUM AND MELARSOPROL
Autore:
MATOVU E; ITEN M; ENYARU JCK; SCHMID C; LUBEGA GW; BRUN R; KAMINSKY R;
Indirizzi:
SWISS TROP INST,SOCINSTR 57 CH-4002 BASEL SWITZERLAND SWISS TROP INST CH-4002 BASEL SWITZERLAND LIVESTOCK HLTH RES INST TORORO UGANDA MAKERERE UNIV,FAC VET MED KAMPALA UGANDA
Titolo Testata:
TM & IH. Tropical medicine & international health
fascicolo: 1, volume: 2, anno: 1997,
pagine: 13 - 18
SICI:
1360-2276(1997)2:1<13:SOUTIF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-SERUM RESISTANCE; SOUTH-EAST UGANDA; DRUG-RESISTANCE; INVITRO; GAMBIENSE; INFECTION; STOCKS; FORMS;
Keywords:
TRYPANOSOMA BRUCEI SPP; TRYPANOSOMA-BRUCEI-RHODESIENSE; ANIMAL RESERVOIR; DRUG SUSCEPTIBILITY; DRUG RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
E. Matovu et al., "SUSCEPTIBILITY OF UGANDAN TRYPANOSOMA-BRUCEI-RHODESIENSE ISOLATED FROM MAN AND ANIMAL RESERVOIRS TO DIMINAZENE, ISOMETAMIDIUM AND MELARSOPROL", TM & IH. Tropical medicine & international health, 2(1), 1997, pp. 13-18

Abstract

Thirty-six Trypanosoma brucei spp. stocks isolated from man and domestic animals in south-east Uganda were studied for susceptibility to diminazene, isometamidium and melarsoprol in vitro. All stocks were susceptible to melarsoprol. One T. b. rhodesiense stock isolated from a sleeping sickness patient showed reduced susceptibility to the veterinary drugs diminazene and isometamidium More than 100 ng/ml diminazene or0.78 ng/ml isometamidium were required to eliminate that stock duringIo days drug exposure. In contrast, the remaining stocks were eliminated by 0.8-6.3 ng/ml diminazene and 0.01-0.20 ng/ml isometamidium. Clones derived from the resistant T. b. rhodesiense stock showed reduced susceptibility to isometamidium and diminazene comparable to the parental population. Control of sleeping sickness by treatment of the animal reservoir could, therefore, face serious problems since drug-resistant stocks as reported here would most likely not be eliminated by recommended doses of diminazene and isometamidium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:22:55