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Titolo:
ANTIVIRAL IMMUNE-RESPONSES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4
Autore:
BACHMANN MF; SCHORLE H; KUHN R; MULLER W; HENGARTNER H; ZINKERNAGEL RM; HORAK I;
Indirizzi:
UNIV ZURICH,INST EXPTL IMMUNOL,DEPT PATHOL,SCHMELZBERGSTR 12 CH-8091 ZURICH SWITZERLAND UNIV WURZBURG,INST IMMUNOL & VIROL W-8700 WURZBURG GERMANY UNIV COLOGNE,INST GENET W-5000 COLOGNE GERMANY
Titolo Testata:
Journal of virology
fascicolo: 8, volume: 69, anno: 1995,
pagine: 4842 - 4846
SICI:
0022-538X(1995)69:8<4842:AIIMDF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR GAMMA-CHAIN; VESICULAR STOMATITIS-VIRUS; CELL STIMULATORY FACTOR; T-CELL; LYMPHOCYTE-T; FUNCTIONAL COMPONENT; GENERATION; IL-4; GENE; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Bachmann et al., "ANTIVIRAL IMMUNE-RESPONSES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4", Journal of virology, 69(8), 1995, pp. 4842-4846

Abstract

Antiviral immune responses of mice lacking interleukin-2 (IL-2) or IL-4 or both IL-2 and IL-4 (IL-2/4) were compared by using different viruses. Primary cytotoxic T-lymphocyte (CTL) responses against lymphocytic choriomeningitis virus (LCMV) were only moderately reduced in mice lacking IL-2 and were normal in mice lacking IL-4. Mice deficient in both interleukins exhibited variable and more strongly reduced but nevertheless in vivo protective LCMV-specific CTL responses. Similar results were obtained with vaccinia virus. Upon virus-specific restimulation in vitro, spleen cells from IL-2- and IL-2/4-deficient mice failed to generate CTL responses against virus-infected target cells, whereas the response of mice deficient in only IL-4 was comparable to that of control mice. The addition of IL-2 during in vitro restimulation completely restored the responses of both IL-2 and IL-2/4-deficient mice. T-helper-cell-independent immunoglobulin M and T-helper-cell-dependent immunoglobulin G antibody responses against vesicular stomatitis virusglycoprotein were within normal ranges for the various mutant mice. After LCMV infection, specific antibody responses against LCMV nucleoprotein were reduced four- to eightfold. These results show that mice lacking IL-2/4 have an overall tendency to exhibit more severely reducedCTL responses than IL-2- or IL-4-deficient mice. Nevertheless, and surprisingly; in vivo protective immune responses were mounted in the absence of IL-2/4, suggesting that besides a minor contribution from IL-4, other interleukins compensate in vivo for the lack of IL-2 in IL-2-deficient mice.

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Documento generato il 01/12/20 alle ore 01:09:17