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Titolo:
HOMOLOGS OF THE SHIGELLA IPAB AND IPAC INVASINS ARE REQUIRED FOR SALMONELLA-TYPHIMURIUM ENTRY INTO CULTURED EPITHELIAL-CELLS
Autore:
KANIGA K; TUCKER S; TROLLINGER D; GALAN JE;
Indirizzi:
SUNY STONY BROOK,SCH MED,DEPT MOLEC GENET & MICROBIOL STONY BROOK NY 11794 SUNY STONY BROOK,SCH MED,DEPT MOLEC GENET & MICROBIOL STONY BROOK NY 11794 AMGEN INC THOUSAND OAKS CA 91320
Titolo Testata:
Journal of bacteriology
fascicolo: 14, volume: 177, anno: 1995,
pagine: 3965 - 3971
SICI:
0021-9193(1995)177:14<3965:HOTSIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
YERSINIA-PSEUDOTUBERCULOSIS; MOLECULAR CHARACTERIZATION; HYPERSENSITIVE RESPONSE; BACTERIAL ATTACHMENT; PLASMID ANTIGENS; ESCHERICHIA-COLI; FLEXNERI; PROTEIN; GENE; INTERNALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
K. Kaniga et al., "HOMOLOGS OF THE SHIGELLA IPAB AND IPAC INVASINS ARE REQUIRED FOR SALMONELLA-TYPHIMURIUM ENTRY INTO CULTURED EPITHELIAL-CELLS", Journal of bacteriology, 177(14), 1995, pp. 3965-3971

Abstract

Entry into host cells is an essential feature in the pathogenicity ofSalmonella spp. The inv locus of Salmonella typhimurium encodes several proteins which are components of a type III protein secretion system required for these organisms to gain access to host cells, We reporthere the identification of several proteins whose secretion into the culture supernatant of S. typhimurium is dependent on the function of the inv-encoded translocation apparatus. Nucleotide sequence analysis of the genes encoding two of these secreted proteins, SipB and SipC, indicated that they are homologous to the Shigella sp. invasins IpaB and IpaC, respectively. An additional gene was identified, sicA, which encodes a protein homologous to IpgC, a Shigella protein that serves asa molecular chaperone for the invasins IpaB and IpaC. Nonpolar mutations in sicA, sipB, and sipC rendered S. typhimurium unable to enter cultured epithelial cells, indicating that these genes are required for bacterial internalization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:53:25