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Titolo:
THE PROGNOSIS AND MAIN PROGNOSTIC INDICATORS OF GUILLAIN-BARRE-SYNDROME - A MULTICENTER PROSPECTIVE-STUDY OF 297 PATIENTS
Autore:
BEGHI E; BONO A; BOGLIUN G; CORNELIO F; RIZZUTO N; TONALI P; ZERBI D; CASTELLI C; FERRARI G; MARCONI N; SIMONE P; APOLLO F; AMORUSO L; CROCIANI P; ZARRELLI M; ANGELINI C; BRIANI C; FINCATI E; AFFUSO R; BOTTACCHI E; LIA C; CARENINI L; VERATTI AM; GUASTELLA G; CANISTRA U; MEINERI P; GRASSO E; BARGAGLI G; GRESTI M; CAVALETTI G; SANTORO P; MARZORATI L; ANTOZZI C; BELLINI A; GENTILINI M; LUNAZZI C; SORGATO P; FASANAR AM; PIZZA V; MIGNOGNA MT; SABATELLI M; LIPPI G; GOMITONI A; LOVASTE MG;
Indirizzi:
IST RIC FARMACOL MARIO NEGRI,UNITA MALATTIE NEUROL,VIA ERITREA 62 I-20157 MILAN ITALY IRCCS,OSPED OSS SAN GIOVANNI ROTO ITALY OSPED SAN GERARDO,NEUROL CLIN MONZA ITALY IST NEUROCHIRURG C BESTA,DIV MALATTIE NEUROMUSCOLARI MILAN ITALY OSPED BORGO ROMA,NEUROL CLIN VERONA ITALY OSPED S CARLO,DIV NEUROL MILAN ITALY OSPED BORGO TRENTO VERONA ITALY CTR TRASFUS & IMMUNOL TRAPIANTI,POLICLIN MILAN ITALY IRCCS,OSPED CASA SOLLIEVO SOFFERENZA,DIV NEUROL SAN GIOVANNI ROTO ITALY UNIV PADUA,NEUROL CLIN PADUA ITALY UNIV VERONA,POLICLIN BORGO ROMA,NEUROL CLIN I-37134 VERONA ITALY POLICLIN,CLIN NEUROL 1 BARI ITALY OSPED REG,UO NEUROL AOSTA ITALY OSPED CATANZARO,SERV TRASFUS CATANZARO ITALY OSPED S CROCE,DIV NEUROL CUNEO ITALY ENTE OSPED,SERV IMMUNOEMATOL GROSSETO ITALY OSPED MODENA,NEUROL CLIN MODENA ITALY OSPED ANTONIO CARDARELLI,DIV NEUROL NAPLES ITALY UNIV CATTOLICA,IST NEUROL,POLICLIN A GEMELLI ROME ITALY OSPED SARONNO,DIV NEUROL SARONNO ITALY OSPED TRENTO,DIV NEUROL TRENT ITALY
Titolo Testata:
Brain
, volume: 119, anno: 1996,
parte:, 6
pagine: 2053 - 2061
SICI:
0006-8950(1996)119:<2053:TPAMPI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAMPYLOBACTER-JEJUNI INFECTION; NORTHERN CHINA; POLYNEUROPATHY; REGENERATION; ANTIBODIES; NEUROPATHY; FEATURES; CHILDREN; TRIAL;
Keywords:
GUILLAIN-BARRE SYNDROME; ACUTE POLYNEURITIS; PROGNOSIS; PROGNOSTIC FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
E. Beghi et al., "THE PROGNOSIS AND MAIN PROGNOSTIC INDICATORS OF GUILLAIN-BARRE-SYNDROME - A MULTICENTER PROSPECTIVE-STUDY OF 297 PATIENTS", Brain, 119, 1996, pp. 2053-2061

Abstract

To assess the prognosis of the Guillain-Barre syndrome and identify the main prognostic indicators, 297 patients with Guillain-Barre syndrome recruited through a network of Italian centres were followed up for24 months or until clinical recovery, whichever was earliest. For each patient the time to plateau, improvement, clinical recovery, or death was calculated, and prognostic indicators (age, sex, antecedent events, disability at admission and nadir electrophysiological patterns) and treatments were noted. The mean duration of follow-up was 309 days. During this period, 212 patients (71%) recovered, 48 (16%) had residua and 33 (11%) died. The mean times to nadir improvement and clinical recovery were 12, 28 and 200 days. Using life-tables and survival curves, the cumulative probability of achieving the plateau of symptoms was 73% by 1 week and 98% by 4 weeks. Improvement started during the first week in 36% of cases and within 4 weeks in 85%. The rates of clinical recovery at 1 and 4 weeks, 6, 12 and 24 months were 4, 24, 57, 70 and 82%, respectively. The chance of recovery was significantly affected by age, antecedent gastroenteritis, disability, electrophysiologicalsigns of axonopathy, latency to nadir and duration of active disease. The main treatments did not seem to affect the chance of recovery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:49:03