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Titolo:
EXPRESSION OF KERATINOCYTE GROWTH-FACTOR IN PERIAPICAL LESIONS
Autore:
GAO Z; FLAITZ CM; MACKENZIE IC;
Indirizzi:
UNIV MICHIGAN,SCH DENT,DEPT CARIOL,1011 N UNIV ANN ARBOR MI 48109 UNIV MICHIGAN,SCH DENT,DEPT CARIOL ANN ARBOR MI 48109 UNIV TEXAS,HLTH SCI CTR,DENT BRANCH HOUSTON TX 77225
Titolo Testata:
Journal of dental research
fascicolo: 9, volume: 75, anno: 1996,
pagine: 1658 - 1663
SICI:
0022-0345(1996)75:9<1658:EOKGIP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR GENE-EXPRESSION; EPITHELIAL-CELL RESTS; LARGE INDUCTION; PROLIFERATION; MALASSEZ; KGF; SPECIFICITY; FAMILY; CYSTS;
Keywords:
KERATINOCYTE GROWTH FACTOR; PERIAPICAL LESIONS; INFLAMMATORY CYSTS; RT/PCR; IN SITU HYBRIDIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
Z. Gao et al., "EXPRESSION OF KERATINOCYTE GROWTH-FACTOR IN PERIAPICAL LESIONS", Journal of dental research, 75(9), 1996, pp. 1658-1663

Abstract

The epithelial proliferation associated with inflammatory periapical lesions and with periapical cyst formation represents an interesting but poorly understood pathological change. Keratinocyte growth factor (KGF) is a recently identified growth factor that is produced by stromal fibroblasts and acts specifically to stimulate epithelial growth anddifferentiation. To investigate its possible role in the activation of the normally quiescent rests of Malassez, we examined the expressionof KGF by in situ hybridization of sections of normal periodontal ligament (PDL) and of 12 periapical granulomas or cysts. Normal PDL and periapical granulomas with scant inflammatory infiltration showed few cells expressing message for KGF. However, KGF-expressing cells were found in the connective tissue stroma close to dense foci of inflammatory cells and to proliferating epithelial elements and cystic epitheliallinings. Examination of tissues by the reverse-transcription polymerase chain reaction (RT-PCR) showed KGF expression in 4 specimens of periapical lesions but low or undetectable levels in normal PDL. These observations suggest that the induction of KGF expression in the stromalcells of periapical lesions may play an important role in stimulatingthe epithelial proliferation associated with cyst formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 09:22:23