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Titolo:
A POSSIBLE INVOLVEMENT OF VIP IN FEEDING-INDUCED SECRETION OF ACTH AND CORTICOSTERONE IN THE RAT
Autore:
ALEXANDER LD; EVANS K; SANDER LD;
Indirizzi:
CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,SCH MED,DIV HYPERTENS,10900 EUCLID AVE CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,SCH MED,DIV HYPERTENS CLEVELAND OH 44106 MEHARRY MED COLL,SCH GRAD STUDIES & RES,DEPT PHYSIOL NASHVILLE TN 37208
Titolo Testata:
Physiology & behavior
fascicolo: 2, volume: 58, anno: 1995,
pagine: 409 - 413
SICI:
0031-9384(1995)58:2<409:APIOVI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL PEPTIDE; CHOLECYSTOKININ OCTAPEPTIDE; CORTISOL SECRETION; PITUITARY-CELLS; CO-EXISTENCE; RELEASE; PHI; POLYPEPTIDE; STIMULATION; PROLACTIN;
Keywords:
PITUITARY; ADRENAL; FOOD-INTAKE; HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS; BRAIN GUT PEPTIDE; RAT; PARAVENTRICULAR NUCLEUS NEUROPEPTIDES; MICROINJECTION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
L.D. Alexander et al., "A POSSIBLE INVOLVEMENT OF VIP IN FEEDING-INDUCED SECRETION OF ACTH AND CORTICOSTERONE IN THE RAT", Physiology & behavior, 58(2), 1995, pp. 409-413

Abstract

For decades it has been known that brainl gut peptides are released during the ingestion of a meal. Although a multitude of actions have been attributed to these peptides acting in the brain, including the release or inhibition of a variety of pituitary hormones, the actual physiological roles of these substances in the brain have not been confirmed. For the first time, we have demonstrated that feeding-induced hypothalamic-pituitary-adrenal (HPA) secretion may involve the brainl gut peptide, vasoactive intestinal peptide (VIP), acting in the paraventricular nucleus (PVN) of the hypothalamus. The effects of 24 h fasting and refeeding on the release of plasma ACTH and CORT secretion in male rats were investigated. Blood samples were collected 5 min prior to PVN administration of saline or VIP antagonist, [Lsy(1),Pro(2,5),Arg(3,4),Tyr(6)]-VIP and 30 min after refeeding. Plasma ACTH and CORT concentrations were significantly increased by 43 and 485%, respectively, by 30 min ingestion of food. Pretreatment with the VIP antagonist (0.75 and 1.5 nmol/rat) significantly reduced the food-induced ACTH response by 69 and 76% and the CORT response by 58 and 65%, respectively. Therewere no significant differences in food-intake among groups. These results suggest that one potential role of hypothalamic VIP may involve activation of hypothalamic-releasing factors to regulate ACTH and CORTlevels during or after a meal.

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Documento generato il 28/11/20 alle ore 09:54:23