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Titolo:
TRANSCRIPTIONAL INDUCTION OF ENDOTHELIAL NITRIC-OXIDE SYNTHASE TYPE-III BY LYSOPHOSPHATIDYLCHOLINE
Autore:
ZEMBOWICZ A; TANG J; WU KK;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV HEMATOL,VASC BIOL RES CTR HOUSTON TX 77030 UNIV TEXAS,HLTH SCI CTR,DEPT INTERNAL MED,DIV HEMATOL HOUSTON TX 77030
Titolo Testata:
The Journal of biological chemistry
fascicolo: 28, volume: 270, anno: 1995,
pagine: 17006 - 17010
SICI:
0021-9258(1995)270:28<17006:TIOENS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEINS; PROTEIN-KINASE-C; CORONARY-ARTERIES; RELAXING FACTOR; DEPENDENT RELAXATION; RABBIT AORTA; VASCULAR REACTIVITY; POTENTIAL ROLE; L-ARGININE; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
A. Zembowicz et al., "TRANSCRIPTIONAL INDUCTION OF ENDOTHELIAL NITRIC-OXIDE SYNTHASE TYPE-III BY LYSOPHOSPHATIDYLCHOLINE", The Journal of biological chemistry, 270(28), 1995, pp. 17006-17010

Abstract

Endothelial synthesis of NO is catalyzed by constitutive NO synthase type III (NOS-III). NOS-III has been thought to be regulated mainly atthe level of enzyme activity by intracellular calcium. We report thatin human umbilical vein endothelial cells lysophosphatidylcholine (lyse-PC), a component of atherogenic lipoproteins and atherosclerotic lesions, increases NOS III mRNA and protein levels. This leads to the augmentation of NOS-III activity and the enhancement of antiplatelet properties of endothelial cells. Importantly, nuclear run-off experimentsdemonstrate a transcriptional mechanism of regulation of NOS-III expression by lysophosphatidylcholine. As endothelium-derived NO appears to be an anti-atherogenic molecule, induction of NOS-III by lyse-PC maybe a protective response that limits the progress of the atherosclerotic lesion and pro motes its regression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 07:30:17