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Titolo:
THE MOLECULAR-BIOLOGY OF HEPATITIS-DELTA VIRUS
Autore:
LAI MMC;
Indirizzi:
UNIV SO CALIF,SCH MED,HOWARD HUGHES MED INST LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT MICROBIOL LOS ANGELES CA 90033
Titolo Testata:
Annual review of biochemistry
, volume: 64, anno: 1995,
pagine: 259 - 286
SICI:
0066-4154(1995)64:<259:TMOHV>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
B SURFACE-ANTIGEN; RNA-BINDING ACTIVITY; VIROID-LIKE DOMAIN; OPEN READING FRAME; SELF-CLEAVAGE; GENOME REPLICATION; HBSAG-CARRIERS; CELL-LINE; INTRAHEPATIC EXPRESSION; WOODCHUCK HEPATOCYTES;
Keywords:
RNA-DEPENDENT RNA SYNTHESIS; RNA-PROTEIN INTERACTION; RNA EDITING; RIBOZYMES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
137
Recensione:
Indirizzi per estratti:
Citazione:
M.M.C. Lai, "THE MOLECULAR-BIOLOGY OF HEPATITIS-DELTA VIRUS", Annual review of biochemistry, 64, 1995, pp. 259-286

Abstract

Hepatitis delta virus (HDV) contains a circular, viroid-like RNA genome, the only animal viral RNA of its kind. It possesses a ribozyme activity, which can autocatalytically cleave and ligate itself. The ribozyme has a unique structural requirement different from other known ribozymes. HDV RNA undergoes RNA-dependent RNA replication via a double rolling circle mechanism, which is probably mediated by cellular RNA polymerase II, utilizing modified cellular transcription machineries. HDV RNA encodes a single protein, hepatitis delta antigen, which is a nuclear, RNA-binding phosphoprotein and required for viral RNA replication. During replication, HDV RNA undergoes a specific RNA editing eventto extend its open reading frame and produce a longer, isoprenylated delta antigen, which suppresses RNA replication and initiates viral particle assembly. Ribozyme, cell-mediated RNA-dependent RNA replication, and RNA editing are some of the unique properties and unresolved issues of the molecular biology of HDV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:06:41