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Titolo:
THE P50 EVOKED-POTENTIAL COMPONENT AND MISMATCH DETECTION IN NORMAL VOLUNTEERS - IMPLICATIONS FOR THE STUDY OF SENSORY GATING
Autore:
BOUTROS NN; TORELLO MW; BARKER BA; TUETING PA; WU SC; NASRALLAH HA;
Indirizzi:
VET ADM MED CTR,DEPT PSYCHIAT,950 CAMPBELL AVE W HAVEN CT 06516 OHIO STATE UNIV,DEPT PSYCHIAT COLUMBUS OH 43210
Titolo Testata:
Psychiatry research
fascicolo: 1, volume: 57, anno: 1995,
pagine: 83 - 88
SICI:
0165-1781(1995)57:1<83:TPECAM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATION INTERVAL; SCHIZOPHRENIA; INHIBITION; WAVE;
Keywords:
ELECTROPHYSIOLOGY; AUDITORY STIMULI; TEMPORAL LOBES; SENSORY INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
N.N. Boutros et al., "THE P50 EVOKED-POTENTIAL COMPONENT AND MISMATCH DETECTION IN NORMAL VOLUNTEERS - IMPLICATIONS FOR THE STUDY OF SENSORY GATING", Psychiatry research, 57(1), 1995, pp. 83-88

Abstract

Sensory gating is a complex, multistage, multifaceted physiological function believed to be protecting higher cortical centers from being flooded with incoming irrelevant sensory stimuli. Failure of such mechanisms is hypothesized as one of the mechanisms underlying the development of psychotic states. Attenuation of the amplitude of the P50 evoked potential component with stimulus repetition is widely used to studysensory gating. In the current study, we investigated the responsiveness of the P50 component to changes in the physical characteristics ofongoing trains of auditory stimuli. Forty normal volunteers were studied in a modified oddball paradigm. At all cerebral locations studied,P50 amplitudes were higher in response to infrequent stimuli. We postulate that the increase in P50 amplitude reflects the system's recognition of novel stimuli or ''gating in'' of sensory input. The ratio of the amplitude of the responses to the infrequent stimuli to those of the frequent stimuli was significantly higher for the posterior temporal regions. This finding provides further evidence that the temporal lobes may be significantly involved in sensory gating processes. Although this study only included normal subjects, the data generated contribute to the understanding of sensory gating mechanisms that may be relevant to psychotic states.

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Documento generato il 11/07/20 alle ore 09:34:26