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Titolo:
SYK AND LYN ARE INVOLVED IN RADIATION-INDUCED SIGNALING, BUT INACTIVATION OF SYK OR LYN ALONE IS NOT SUFFICIENT TO PREVENT RADIATION-INDUCED APOPTOSIS
Autore:
YANG C; MARUYAMA S; YANAGI S; WANG XY; TAKATA M; KUROSAKI T; YAMAMURA H;
Indirizzi:
KOBE UNIV,SCH MED,DEPT BIOCHEM,CHUO KU KOBE 650 JAPAN KOBE UNIV,SCH MED,DEPT BIOCHEM,CHUO KU KOBE 650 JAPAN FUKUI MED SCH,DEPT BIOCHEM MATSUOKA FUKUI 91011 JAPAN AMER CYANAMID CO,LEDERLE LABS,DEPT CARDIOVASC MOLEC BIOL PEARL RIVER NY 10965 YALE UNIV,SCH MED,IMMUNOBIOL SECT NEW HAVEN CT 06510
Titolo Testata:
Journal of Biochemistry
fascicolo: 1, volume: 118, anno: 1995,
pagine: 33 - 38
SICI:
0021-924X(1995)118:1<33:SALAII>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN TYROSINE PHOSPHORYLATION; LYMPHOCYTE-B PRECURSORS; CELL-DEATH; IONIZING-RADIATION; KINASE P72(SYK); ACTIVATION; STIMULATION; THYMOCYTES; PLATELETS;
Keywords:
APOPTOSIS; IONIZING RADIATION; LYN; SIGNAL TRANSDUCTION; SYK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C. Yang et al., "SYK AND LYN ARE INVOLVED IN RADIATION-INDUCED SIGNALING, BUT INACTIVATION OF SYK OR LYN ALONE IS NOT SUFFICIENT TO PREVENT RADIATION-INDUCED APOPTOSIS", Journal of Biochemistry, 118(1), 1995, pp. 33-38

Abstract

Radiation-induced biochemical events that mediate the intracellular signal transduction leading to cell apoptosis are largely unknown, Limited evidence suggests the possible involvement of one or more protein-tyrosine kinases (PTKs) in radiation-induced cellular responses, including apoptosis, However, so far, a PTK(s) responsible for the radiation-induced tyrosine phosphorylation of cellular substrates has not beenidentified and the role of the PTK(s) in the radiation-induced apoptosis remains unclear. To examine the roles of Syk and Lyn in radiation-induced signal transduction and radiation-induced apoptosis, we analyzed Syk-deficient or Lyn-deficient DT40 B cells along with wild-type cells following radiation, When DT40 B cells were exposed to radiation, the activity of Syk kinase dramatically increased and reached a maximum with 0.25 Grays (Gy) (15 s), and then decreased, whereas Lyn kinase activity increased and reached a maximum with a dose of 1.00 Gy (1 min), However, an apparent difference was not observed in radiation-induced apoptosis among wild-type, Syk-deficient, and Lyn-deficient DT40 B cells, These results indicate that Syk and Lyn kinases are involved inradiation-induced signal transduction, with different kinetics, In addition, our results revealed that functional inactivation of Syk or Lyn alone is not sufficient to prevent radiation-induced apoptosis, Thus, it is suggested that the activation of Syk or Lyn kinase alone may be sufficient to mediate the radiation-induced apoptosis in DT40 B cells, or both kinases may not be required for this biological process.

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Documento generato il 14/07/20 alle ore 13:14:36