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Titolo:
ALTERNATIVE APPLICATION OF MELARSOPROL FOR TREATMENT OF TB-GAMBIENSE SLEEPING SICKNESS - PRELIMINARY-RESULTS
Autore:
BURRI C; BLUM J; BRUN R;
Indirizzi:
SWISS TROP INST CH-4002 BASEL SWITZERLAND SWISS TROP INST CH-4002 BASEL SWITZERLAND
Titolo Testata:
Annales de la Societe belge de medecine tropicale
fascicolo: 1, volume: 75, anno: 1995,
pagine: 65 - 71
SICI:
0772-4128(1995)75:1<65:AAOMFT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFRICAN TRYPANOSOMIASIS; INDUCED ENCEPHALOPATHY;
Keywords:
AFRICAN TRYPANOSOMIASIS; TRYPANOSOMA GAMBIENSE; CHEMOTHERAPY; MELARSOPROL; ALTERNATIVE TREATMENT PROTOCOL; ZAIRE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
C. Burri et al., "ALTERNATIVE APPLICATION OF MELARSOPROL FOR TREATMENT OF TB-GAMBIENSE SLEEPING SICKNESS - PRELIMINARY-RESULTS", Annales de la Societe belge de medecine tropicale, 75(1), 1995, pp. 65-71

Abstract

The protocols for treatment of human African trypanosomiasis (sleeping sickness) with the organoarsenical drug melarsoprol are based on empirical observations. Therapy is often accompanied by serious side effects and relapses. Additionally, the duration of treatment, which is upto forty days, is a major drawback in African countries. Based on pharmacokinetic investigations an alternative therapy protocol for T. gambiense sleeping sickness has recently been proposed which consists of ten consecutive injections of 2.2 mg/kg melarsoprol given at intervalsof 24 hours. In a preliminary study eleven patients were treated in Vanga, Zaire following this alternative protocol which reduces the duration of the treatment to ten days. The results indicate that the alternative schedule was as effective as the traditional protocol, showed similar adverse reactions but required a much shorter treatment period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:25:23