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Titolo:
THE EFFECTS OF MIDAZOLAM, DROPERIDOL, FENTANYL, AND ALFENTANIL ON PHAGOCYTOSIS AND KILLING OF BACTERIA BY POLYMORPHONUCLEAR LEUKOCYTES IN-VITRO
Autore:
KRUMHOLZ W; ENDRASS J; KNECHT J; HEMPELMANN G;
Indirizzi:
UNIV GIESSEN,DEPT ANAESTHESIOL & INTENS CARE MED,KLIN STR 29 D-35392 GIESSEN GERMANY
Titolo Testata:
Acta anaesthesiologica Scandinavica
fascicolo: 5, volume: 39, anno: 1995,
pagine: 624 - 627
SICI:
0001-5172(1995)39:5<624:TEOMDF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS ANESTHETICS; INVITRO; PHARMACOKINETICS; NEUTROPHILS;
Keywords:
ALFENTANIL; BACTERICIDAL ACTIVITY; DROPERIDAL; FENTANYL; MIDAZOLAM; PHAGOCYTOSIS; POLYMORPHONUCLEAR; LEUKOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
W. Krumholz et al., "THE EFFECTS OF MIDAZOLAM, DROPERIDOL, FENTANYL, AND ALFENTANIL ON PHAGOCYTOSIS AND KILLING OF BACTERIA BY POLYMORPHONUCLEAR LEUKOCYTES IN-VITRO", Acta anaesthesiologica Scandinavica, 39(5), 1995, pp. 624-627

Abstract

Polymorphonuclear leukocytes (PMNL) make an outstanding contribution to the defence against invading bacteria. We studied the effects of midazolam, droperidol, fentanyl, and alfentanil on phagocytosis and killing of Staphylococcus arueus and Escherichia coli by PMNL in vitro. Using a method described by Eggleton et al. (5), PMNL were isolated fromvenous blood samples obtained from ten volunteers. The fluorescence microscopic method mentioned by Bellinati-Pires et al. (6) was used to examine phagocytosis and killing. Whereas both midazolam and droperidol caused a significant inhibition of phagocytosis as well as bactericidal activity, fentanyl and alfentanil did not influence these PMNL functions. In order to find out whether midazolam and droperidol are ableto intensify perioperative bacterial infections in vivo as well, additional clinical studies should be conducted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 09:31:32