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Titolo:
COMPUTED TOMOGRAPHY-IDENTIFIED BUT NOT MAGNETIC-RESONANCE IMAGING-IDENTIFIED PERIVENTRICULAR WHITE-MATTER LESIONS PREDICT SYMPTOMATIC CEREBROVASCULAR-DISEASE IN PROBABLE ALZHEIMERS-DISEASE
Autore:
LOPEZ OL; BECKER JT; JUNGREIS CA; REZEK D; ESTOL C; BOLLER F; DEKOSKY ST;
Indirizzi:
NEUROPSYCHOL RES PROGRAM,3600 FORBES AVE,SUITE 502 PITTSBURGH PA 15213 UNIV PITTSBURGH,DEPT NEUROL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT PSYCHIAT PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT NEUROSURG PITTSBURGH PA 15260 UNIV PITTSBURGH,ALZHEIMERS DIS RES CTR PITTSBURGH PA 15260 INST CARDIOVASC BUENOS AIRES BUENOS AIRES DF ARGENTINA CTR PAUL BROCA,INSERM,U324 PARIS FRANCE UNIV PITTSBURGH,DEPT RADIOL NEURORADIOL PITTSBURGH PA 00000
Titolo Testata:
Archives of neurology
fascicolo: 7, volume: 52, anno: 1995,
pagine: 659 - 664
SICI:
0003-9942(1995)52:7<659:CTBNMI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKO-ARAIOSIS; VASCULAR DEMENTIA; BRAIN LUCENCIES; BLOOD-FLOW; CT; MR; HYPERINTENSITIES; COGNITION; LEUKOENCEPHALOPATHY; IMAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
O.L. Lopez et al., "COMPUTED TOMOGRAPHY-IDENTIFIED BUT NOT MAGNETIC-RESONANCE IMAGING-IDENTIFIED PERIVENTRICULAR WHITE-MATTER LESIONS PREDICT SYMPTOMATIC CEREBROVASCULAR-DISEASE IN PROBABLE ALZHEIMERS-DISEASE", Archives of neurology, 52(7), 1995, pp. 659-664

Abstract

Objective: To examine the clinical consequences of periventricular white-matter lesions on computed tomography (CT) and magnetic resonance imaging (MRI) scans in probable Alzheimer's disease. Design: Case series, 12-month follow-up. Setting: Multidisciplinary behavioral neurology research clinic. Patients: We longitudinally evaluated the clinical characteristics of 27 patients with probable AD for whom both CT and MRI scans had been performed at baseline. Interventions: None. Main Outcome Measure: The presence of abnormal neurological signs was examinedat baseline and at a 12-month examination. Results: Periventricular white-matter lesions were observed with CT in 12 patients (44%) and with MRI in 21 patients (78%). Computed tomography did nor detect lesionsof 1 to 3 mm, as were seen on MRI scans, and CT also did not detect lesions of 4 to 10 mm when they occurred in the deep subcortical white matter and were not part of a greater confluent lesion. There was no relationship between the severity of periventricular white-matter lesions with either neuroimaging method and the presence of abnormal neurological signs. However, there was a greater frequency of periventricular white-matter lesions shown on CT scans than on MRI scans at baselinein patients in whom abnormal neurological signs leg, abnormal gait, asymmetric deep tendon reflexes, focal motor deficits, abnormal plantarresponse) developed at 12-month follow-up. Conclusion: Although MRI may be more sensitive in detecting periventricular white-matter lesions, CT is more specific in predicting subsequent symptomatic cerebrovascular disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 07:31:34