Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FACTORS INFLUENCING EFFICACY OF EXOGENOUS SURFACTANT IN ACUTE LUNG INJURY
Autore:
LEWIS JF; VELDHUIZEN RAW;
Indirizzi:
UNIV WESTERN ONTARIO,ST JOSEPHS HLTH CTR,LAWSON RES INST,DEPT MED,268GROSVENOR ST LONDON ON N6A 4V2 CANADA
Titolo Testata:
Biology of the neonate
, volume: 67, anno: 1995, supplemento:, 1
pagine: 48 - 60
SICI:
0006-3126(1995)67:<48:FIEOES>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; BOVINE PULMONARY SURFACTANT; CHEMICAL-COMPOSITION; RANDOMIZED TRIAL; METABOLISM; PROTEINS; CONVERSION; PREVENTION; THERAPY; FAILURE;
Keywords:
SURFACTANT; LUNG INJURY; ACUTE RESPIRATORY DISTRESS SYNDROME; SURFACTANT REPLACEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Lewis e R.A.W. Veldhuizen, "FACTORS INFLUENCING EFFICACY OF EXOGENOUS SURFACTANT IN ACUTE LUNG INJURY", Biology of the neonate, 67, 1995, pp. 48-60

Abstract

Exogenous surfactant is currently being tested as a therapeutic modality for patients with acute respiratory distress syndrome (ARDS). Animal studies have shown that several factors may influence the efficacy of this treatment modality. These factors include the surfactant delivery method used (instillation vs. aerosolization), the timing of surfactant treatment over the course of injury, the specific surfactant preparation used, and the dose of surfactant administered. Each of these factors alone and together may influence the interaction of the exogenous surfactant with the host's alveolar environment. This, in turn, may dictate how a specific patient responds to a particular surfactant treatment strategy. It is suggested that patients at an early stage of lung injury will benefit from aerosolized exogenous surfactant whereaslarge quantities of an instilled exogenous surfactant may be necessary at later stages of injury. Future studies will clarify how a specific surfactant treatment strategy should be chosen for an individual patient with ARDS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:09:46