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Titolo:
THROMBOLYSIS OF MODIFIED BLALOCK-TAUSSIG- SHUNTS IN INFANCY WITH RECOMBINANT PLASMINOGEN-ACTIVATOR
Autore:
KLINGE J; HOFBECK M; RIES M; SCHAF J; SINGER H; VONDEREMDE J;
Indirizzi:
UNIV ERLANGEN NURNBERG,KINDER & JUGENDLICHE KLIN & POLIKLIN,INTENSIVSTN,LOSCHGESTR 15 D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,CHIRURG KLIN,HERZCHIRURG ABT D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,KINDER & JUGENDLICHE KLIN & POLIKLIN,KINDERKARDIOL ABT D-91054 ERLANGEN GERMANY
Titolo Testata:
Zeitschrift fur Kardiologie
fascicolo: 6, volume: 84, anno: 1995,
pagine: 476 - 480
SICI:
0300-5860(1995)84:6<476:TOMBSI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
GER
Soggetto:
VENOUS THROMBOSIS; RT-PA; VENA-CAVA; CHILDREN; ALTEPLASE; THERAPY; ARTERIAL; NEONATE; LYSIS;
Keywords:
BLALOCK-TAUSSIG-SHUNT; THROMBOSIS; THROMBOLYSIS; RECOMBINANT PLASMINOGEN ACTIVATOR; CONGENITAL HEART DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J. Klinge et al., "THROMBOLYSIS OF MODIFIED BLALOCK-TAUSSIG- SHUNTS IN INFANCY WITH RECOMBINANT PLASMINOGEN-ACTIVATOR", Zeitschrift fur Kardiologie, 84(6), 1995, pp. 476-480

Abstract

Since 1983, when c-DNA was isolated, recombinant tissue plasminogen activator (rtPA), an endothelial-cell-produced activator of fibrinolysis is used, more increasingly often in therapy of thrombosis. Whereas some studys have been published regarding efficacy and safety of rtPA in different thrombotic states of adults, only case reports exist in children. Doses vary widely (0.8-6 mg/kg/d), bleeding complications are reported in up to 50%. We report on four infants with complex cyanoticcongenital heart disease who developed an early postoperative thrombosis of a modified Blalock-Taussig shunt. By local low dosage application of rtPA we could achieve a complete lysis of the thrombus in three of our four patients. In one patient we were unsuccessful due to a distal stenosis of the shunt. This infant required repeat surgery with creation of a central aortopulmonary shunt. We saw severe bleeding in one, requiring transfusion of packed cells, and formation of a perigraftreaction in another patient. In our experience local application of rtPA in low doses is a good therapeutical option in patients with thrombosis of aorto-pulmonary shunts, especially in the first postoperativedays.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:02:29