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Titolo:
A COMPARISON OF BETA-CAROTENE AND VITAMIN-A EFFECTS ON A HEPATOCARCINOGENESIS MODEL
Autore:
MORENO FS; WU TS; PENTEADO MVC; RIZZI MBS; JORDAO AA; ALMEIDAMURADIAN LB; DAGLI MLZ;
Indirizzi:
UNIV SAO PAULO,FAC CIENCIAS FARMACEUT,DEPT ALIMENTOS & NUTR EXPTL,BLOCO 14,CAIXA POSTAL 66083 BR-05389970 SAO PAULO SP BRAZIL UNIV SAO PAULO,FAC VET MED & ZOOTECHNY,DEPT PATHOL BR-05389970 SAO PAULO SP BRAZIL
Titolo Testata:
International journal for vitamin and nutrition research
fascicolo: 2, volume: 65, anno: 1995,
pagine: 87 - 94
SICI:
0300-9831(1995)65:2<87:ACOBAV>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROVITAMIN-A; METABOLISM; RAT; CANCER; TRANSFORMATION; CARCINOGENESIS; CONVERSION; LIVER;
Keywords:
HEPATOCARCINOGENESIS; VITAMIN-A; BETA-CAROTENE; PROVITAMIN A; INTRINSIC ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
F.S. Moreno et al., "A COMPARISON OF BETA-CAROTENE AND VITAMIN-A EFFECTS ON A HEPATOCARCINOGENESIS MODEL", International journal for vitamin and nutrition research, 65(2), 1995, pp. 87-94

Abstract

The effects of beta-carotene (beta C) or vitamin A (VA) administration for 8 consecutive weeks were compared in male Wistar rats submitted to the resistant hepatocyte model (RH model) of hepatocarcinogenesis. Animals treated with corn oil (GO), instead of carotenoid or retinoid,sewed as controls. At the end of the study beta C treatment resulted in a substancial reduction in the hepatocyte nodule incidence, total number of nodules and in the nodule multiplicity, as well as in the number and size of hepatic gamma-glutamyltranspeptidase (gamma GT)-positive foci. In contrast, animals administered with VA presented a 100% nodule incidence, and only a moderate decrease in the total number of hepatocyte nodules. These showed to be in the great majority larger thannodules observed after beta C treatment. Moreover VA administration resulted in similar number and size of gamma GT-positive foci than controls. In addition, the hepatic concentrations of total VA increased inboth, BC and VA treated animals. However as expected, increases in the hepatic carotenoid concentrations could be only observed after beta C application. Therefore, changes in the hepatic levels of beta C, andnot of VA, resulted in appreciable inhibitory effects on preneoplastic lesions of the liver. The evidence implies that the chemopreventive property of beta C is unrelated to its provitamin A activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 09:35:39