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Titolo:
EPICARDIAL VASOMOTOR RESPONSES TO ACETYLCHOLINE ARE NOT PREDICTED BY CORONARY ATHEROSCLEROSIS AS ASSESSED BY INTRACORONARY ULTRASOUND
Autore:
NISHIMURA RA; LERMAN A; CHESEBRO JH; ILSTRUP DM; HODGE DO; HIGANO ST; HOLMES DR; TAJIK AJ;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV CARDIOVASC DIS & INTERNAL MED,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,BIOSTAT SECT ROCHESTER MN 55905
Titolo Testata:
Journal of the American College of Cardiology
fascicolo: 1, volume: 26, anno: 1995,
pagine: 41 - 49
SICI:
0735-1097(1995)26:1<41:EVRTAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; VASCULAR SMOOTH-MUSCLE; ARTERIAL DIAMETER; INVIVO; DYSFUNCTION; VASODILATION; DISEASE; INVITRO; ANGINA; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Nishimura et al., "EPICARDIAL VASOMOTOR RESPONSES TO ACETYLCHOLINE ARE NOT PREDICTED BY CORONARY ATHEROSCLEROSIS AS ASSESSED BY INTRACORONARY ULTRASOUND", Journal of the American College of Cardiology, 26(1), 1995, pp. 41-49

Abstract

Objectives. The purpose of this study was to use intravascular ultrasound to determine the morphologic appearance of the coronary arteries,relating the absence, presence and extent of atherosclerosis to the response of the coronary arteries to acetylcholine infusion. Background. Endothelial function plays a major role in the pathophysiology of myocardial ischemia and angina pectoris. The response of the coronary arteries to selective infusion of acetylcholine has been used to examineendothelial function, with vasoconstriction occurring in the absence of intact endothelial function. Vasoconstriction to acetylcholine infusion in humans without overt coronary artery disease has been attributed to early atherosclerosis not detected by coronary angiography. Methods. Twenty-nine patients without overt coronary artery disease underwent selective coronary angiography and selective intracoronary infusion of increasing concentrations of acetylcholine (10(-6), 10(-5) and 10(-4) mol/liter), followed by intravascular ultrasound imaging. Results. The response of the coronary arteries to acetylcholine infusion was not dependent on the absence or presence of atherosclerotic plaque, asdetected by intravascular ultrasound. The percent change in epicardial coronary artery diameter during acetylcholine infusion versus baseline was -14 +/- 28% (mean +/- SD) in the seven patients with no visibleatherosclerosis on intravascular ultrasound versus -9 +/- 20% in the 22 patients with visible atherosclerosis on intravascular ultrasound (p = NS, confidence interval -14% to 25%). There was a greater vasoconstrictive response to acetylcholine infusion in patients with risk factors for coronary artery disease than in those without risk factors (p = 0.003). Conclusions. The vasoreactive response to acetylcholine is not necessarily dependent on ultrasound detection of the presence or absence of atherosclerosis.

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Documento generato il 15/07/20 alle ore 13:59:31