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Titolo:
HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION AND PH-DEPENDENT ELECTROCHEMICAL PROPERTIES OF PYRROLOQUINOLINE QUINONE AND 3 CLOSELY-RELATED ISOMERIC ANALOGS
Autore:
ZHANG ZP; TILLEKERATNE LMV; KIRCHHOFF JR; HUDSON RA;
Indirizzi:
UNIV TOLEDO,COLL PHARM,DEPT MED & BIOL CHEM,2801 W BANCROFT ST TOLEDOOH 43606 UNIV TOLEDO,COLL PHARM,DEPT MED & BIOL CHEM TOLEDO OH 43606 UNIV TOLEDO,COLL ARTS & SCI,DEPT CHEM TOLEDO OH 43606
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 212, anno: 1995,
pagine: 41 - 47
SICI:
0006-291X(1995)212:1<41:HLSAPE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
COENZYME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
Z.P. Zhang et al., "HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION AND PH-DEPENDENT ELECTROCHEMICAL PROPERTIES OF PYRROLOQUINOLINE QUINONE AND 3 CLOSELY-RELATED ISOMERIC ANALOGS", Biochemical and biophysical research communications, 212(1), 1995, pp. 41-47

Abstract

Pyrroloquinoline quinone 1 (PQQ, methoxatin, oxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid) is a novel coenzyme. Closely related isomeric analogues of PQQ may be formed in nature and may possess PQQ-like functions. Here, the electrochemical pH-dependent properties and the high performance liquid chromatographic (HPLC) separation protocols are reported for three major isomeric PQQ analogues likely to be formed in nature. The electrochemical data (cyclic voltammetry) provided the pK(a)s of the five ionizable groups in each isomeric pQQ The HPLC protocols provide the means of investigating the formation of PQQ and the PQQ isomers reported here during the normal turnover of eukaryoticamine oxidases containing integral topaquinone residues, as well as from direct enzyme-mediated reactions which remain to be characterized. (C) 1995 Academic Press. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:48:11