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Titolo:
MALONDIALDEHYDE-MODIFIED HDL LEADS TO ACCUMULATION OF CHOLESTEROL IN RAT-LIVER ENDOTHELIAL-CELLS
Autore:
GUERTIN F; BRUNET S; GAVINO V; TUCHWEBER B; LEVY E;
Indirizzi:
UNIV MONTREAL,HOP ST JUSTINE,CTR RECH,3175 COTE ST CATHERINE MONTREALPQ H3T 1C5 CANADA UNIV MONTREAL,HOP ST JUSTINE,CTR RECH MONTREAL PQ H3T 1C5 CANADA UNIV MONTREAL,DEPT NUTR MONTREAL PQ H3T 1C5 CANADA
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 212, anno: 1995,
pagine: 1 - 8
SICI:
0006-291X(1995)212:1<1:MHLTAO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; HUMAN MONOCYTE-MACROPHAGES; SCAVENGER RECEPTOR; OXIDATIVE MODIFICATION; HEART-DISEASE; FIBROBLASTS; RECOGNITION; KUPFFER; EFFLUX; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
F. Guertin et al., "MALONDIALDEHYDE-MODIFIED HDL LEADS TO ACCUMULATION OF CHOLESTEROL IN RAT-LIVER ENDOTHELIAL-CELLS", Biochemical and biophysical research communications, 212(1), 1995, pp. 1-8

Abstract

In order to study in vivo the effect of modified high density lipoprotein (HDL) on the movement of free cholesterol to liver cells and bile, we injected i.v. into rats, native or malondialdehyde modified HDL labelled with [C-14]cholesterol. Bile analysis indicated that the contribution of labelled cholesterol to bile acid secretion was diminished in the group receiving MDA-modified HDL when compared to control group. On the other hand, the liver analysis revealed higher radioactivity in the treated group. A separation of liver cells into parenchymal, endothelial, and kupffer at 90 min after the injection of MDA-modified HDL or native HDL indicated that the endothelial cell uptake of labelled free cholesterol from MDA-modified HDL was 2.6-fold higher than for native HDL. It is suggested that liver endothelial cells may be involved in the protection against atherogenoic oxidized lipoprotein. However, with regard to our finding, the uptake of cholesterol from modifiedHDL was detrimental to bile acid secretion. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 15:13:24