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Titolo:
ELECTROPHYSIOLOGICAL EVIDENCE FOR THE ANTINOCICEPTIVE EFFECT OF TRANSCUTANEOUS ELECTRICAL-STIMULATION ON MECHANICALLY EVOKED RESPONSIVENESSOF DORSAL HORN NEURONS IN NEUROPATHIC RATS
Autore:
LEEM JW; PARK ES; PAIK KS;
Indirizzi:
YONSEI UNIV,COLL MED,DEPT PHYSIOL,CPO BOX 8044 SEOUL 120752 SOUTH KOREA
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 192, anno: 1995,
pagine: 197 - 200
SICI:
0304-3940(1995)192:3<197:EEFTAE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCIATIC-NERVE INJURY; PERIPHERAL NEUROPATHY; EXPERIMENTAL-MODEL; PAIN; SYMPATHECTOMY; ACUPUNCTURE; DISORDERS; LIGATION;
Keywords:
NEUROPATHY; PAIN; ALLODYNIA; HYPERALGESIA; ANALGESIA; ELECTROACUPUNCTURE; WIDE DYNAMIC RANGE; SPINAL CORD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Leem et al., "ELECTROPHYSIOLOGICAL EVIDENCE FOR THE ANTINOCICEPTIVE EFFECT OF TRANSCUTANEOUS ELECTRICAL-STIMULATION ON MECHANICALLY EVOKED RESPONSIVENESSOF DORSAL HORN NEURONS IN NEUROPATHIC RATS", Neuroscience letters, 192(3), 1995, pp. 197-200

Abstract

Using a rat model of peripheral neuropathy induced by a tight ligation of L5-6 spinal nerves, the effects of transcutaneous electrical stimulation on the mechanical responses of wide dynamic range (WDR) dorsalhorn neurons were investigated. The responses of the WDR neurons to both the brush and pinch stimuli were found to be enhanced in the neuropathic rats compared to those in the normal rats. These enhanced responses were depressed by low-frequency and high-intensity transcutaneouselectrical stimulation (2 Hz, 4-5 mA) applied to the somatic receptive field. The durations of the depressive effects on the brush responses ranged between 30 and 45 min and those on the pinch responses were 60-90 min. These results imply that the transcutaneous electrical stimulation used here produces an antinociceptive effect via a depressive action on the enhanced mechanical responsiveness of the spinal neurons in this rat model of peripheral neuropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 02:27:27