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Titolo:
CADHERINS AND LANGERHANS CELL IMMUNOBIOLOGY
Autore:
UDEY MC;
Indirizzi:
NCI,DERMATOL BRANCH,NIH,BLDG 10,ROOM 12N254 BETHESDA MD 20892
Titolo Testata:
Clinical and experimental immunology
, volume: 107, anno: 1997, supplemento:, 1
pagine: 6 - 8
SICI:
0009-9104(1997)107:<6:CALCI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULE E-CADHERIN; DENDRITIC CELLS; ADHESION MOLECULE; CONTACT SENSITIVITY; PEMPHIGUS-VULGARIS; LEISHMANIA-MAJOR; PROTEIN ANTIGENS; LYMPH-NODES; T-CELLS; EXPRESSION;
Keywords:
ADHESION; CADHERINS; IMMUNOBIOLOGY; LANGERHANS CELLS; SKIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Udey, "CADHERINS AND LANGERHANS CELL IMMUNOBIOLOGY", Clinical and experimental immunology, 107, 1997, pp. 6-8

Abstract

Langerhans cells represent the epidermal contingent of a family of potent accessory cells termed 'dendritic cells'. Langerhans cells (and perhaps related cells in the dermis) are thought to be required for immune responses directed against foreign antigens and neoantigens that are encountered in skin. The 'life cycle' of the Langerhans cell is characterized by at least two distinct stages. Langerhans cells in epidermis (the 'sentinels') can ingest particulates and process antigens efficiently, but are weak stimulators of unprimed T cells. In contrast, Langerhans cells that have been induced to migrate to lymph nodes aftercontact with antigen in epidermis (the 'messengers') are not phagocytic and have limited antigen-processing capabilities, but are potent stimulators of naive T cells. If Langerhans cells are to fulfil both their 'sentinel' and 'messenger' roles, they must be able to persist in epidermis for considerable periods, and also be able to exit epidermis in a controlled fashion after exposure to antigen. Thus, regulation ofLangerhans cell-keratinocyte adhesion represents a key control point in Langerhans cell trafficking and function. Langerhans cells express E-cadherin, a hemophilic adhesion molecule that is prominently represented in epithelia. Keratinocytes also express this adhesion molecule, and E-cadherin clearly mediates adhesion of murine Langerhans cells tokeratinocytes in vitro. We presume that E-cadherin is involved in thelocalization of Langerhans cells in epidermis. Murine thymocytes alsoexpress E-cadherin early in the course of their development, and it is likely that E-cadherin plays an as yet uncharacterized role in thymocyte-thymic epithelial cell adhesion and in T-cell development. Recently, it has also been demonstrated that some cutaneous T-cell lymphoma cell lines are E-cadherin(+), so E-cadherin may also mediate clinically important leucocyte-epithelial interactions in disease states.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:31:13