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Titolo:
TYROSINE KINASES IN MEGAKARYOCYTOPOIESIS
Autore:
AVRAHAM H; ELLIS MH; JHUN BH; RAJA S; CHALASANI D; AVRAHAM S;
Indirizzi:
HARVARD UNIV,NEW ENGLAND DEACONESS HOSP,SCH MED,DIV HEMATOL ONCOL,1 DEACONESS RD BOSTON MA 02215
Titolo Testata:
Stem cells
fascicolo: 4, volume: 13, anno: 1995,
pagine: 380 - 392
SICI:
1066-5099(1995)13:4<380:TKIM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; COLONY-STIMULATING FACTOR; STEM-CELL FACTOR; PDGF BETA-RECEPTOR; FACTOR-I RECEPTOR; C-KIT LIGAND; CYTOPLASMIC SIGNALING PROTEINS; FOCAL ADHESION KINASE; SH2 DOMAINS; MOLECULAR-CLONING;
Keywords:
TYROSINE KINASES; MEGAKARYOCYTOPOIESIS; CYTOKINES; GROWTH FACTOR RECEPTORS; SIGNAL TRANSDUCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
141
Recensione:
Indirizzi per estratti:
Citazione:
H. Avraham et al., "TYROSINE KINASES IN MEGAKARYOCYTOPOIESIS", Stem cells, 13(4), 1995, pp. 380-392

Abstract

Protein-tyrosine kinases (PTKs) are of vital importance in a variety of cell functions. Recent studies have provided considerable insight into the binding of growth factors to tyrosine kinase receptors and theconsequent induction of signal pathways that lead to a biologic response. Future studies will further delineate the signals that result in a proliferative response and those that induce a differentiation response. Current studies, reviewed here, indicate an important biologic role for PTKs in the regulation of megakaryocyte development and maturation, Whether PTKs function in megakaryocytes in signaling pathways that are similar to pathways in other cells will need to be examined in future studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:39:17