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Titolo:
ADRENAL 21-HYDROXYLASE DEFICIENCY IN CHILDHOOD - 25 YEARS EXPERIENCE
Autore:
LIM YJ; BATCH JA; WARNE GL;
Indirizzi:
ROYAL CHILDRENS HOSP,CTR HORMONE RES,FLEMINGTON RD PARKVILLE VIC 3052AUSTRALIA ROYAL CHILDRENS HOSP,CTR HORMONE RES PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
Journal of paediatrics and child health
fascicolo: 3, volume: 31, anno: 1995,
pagine: 222 - 227
SICI:
1034-4810(1995)31:3<222:A2DIC->2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT HEIGHT; HYPERPLASIA; THERAPY;
Keywords:
AMBIGUOUS GENITALIA; CONGENITAL ADRENAL HYPERPLASIA; HEIGHT; 21-HYDROXYLASE DEFICIENCY; VIRILIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
Y.J. Lim et al., "ADRENAL 21-HYDROXYLASE DEFICIENCY IN CHILDHOOD - 25 YEARS EXPERIENCE", Journal of paediatrics and child health, 31(3), 1995, pp. 222-227

Abstract

Objective: To review past and present management of congenital adrenal hyperplasia at a single centre, as a guide to best practice. Methodology: The records of 89 patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency managed in a children's hospital in Australia over a period of 25 years were reviewed. Results: The diagnosis was made in infancy in 66 patients (37 males and 29 females) and later in 23 (11 males and 12 females). The mean age for genitoplasty in females with ambiguous genitalia was 18 months before 1984 and 3 monthsthereafter. Significant differences were found between males and females presenting after infancy with regard to virilization, bone age advancement, risk of true precocious puberty and final height. The mean final height standard deviation scores for seven males and seven females treated from infancy were -1.32 and -1.26, respectively. Conclusions: The results emphasize the importance of early diagnosis and good control in ensuring a good outcome for patients with 21-hydroxylase deficiency.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 02:25:45