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Titolo:
PRENATAL PHTHALATE CAUSES CRYPTORCHIDISM POSTNATALLY BY INDUCING TRANSABDOMINAL ASCENT OF THE TESTIS IN FETAL RATS
Autore:
IMAJIMA T; SHONO T; ZAKARIA O; SUITA S;
Indirizzi:
KYUSHU UNIV,FAC MED,DEPT PEDIAT SURG,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 81282 JAPAN
Titolo Testata:
Journal of pediatric surgery
fascicolo: 1, volume: 32, anno: 1997,
pagine: 18 - 21
SICI:
0022-3468(1997)32:1<18:PPCCPB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TESTICULAR DESCENT; SERTOLI CELLS; MIGRATION; MODEL; MICE;
Keywords:
PHTHALATE ESTERS; CRYPTORCHIDISM; TRANSABDOMINAL DESCENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
T. Imajima et al., "PRENATAL PHTHALATE CAUSES CRYPTORCHIDISM POSTNATALLY BY INDUCING TRANSABDOMINAL ASCENT OF THE TESTIS IN FETAL RATS", Journal of pediatric surgery, 32(1), 1997, pp. 18-21

Abstract

Phthalate esters, which are commonly used as plasticizers for polyvinyl chloride, are also well known to disturb Sertoli cells. This study aims to show the effect of prenatally administered phthalate on testicular descent in pre- and postnatal rats. Pregnant rats were exposed tomono-n-butyl phthalate (MBP) by gavage from the 15th to the 18th gestational days. Rats administered with solvent only were used as controls. In 20-day-old fetuses (n = 15), the degree of transabdominal testicular ascent in relation to the bladder neck was thus found to be significantly higher in MBP-treated rats than that of the controls (n = 19). In addition, in MBP-treated male offspring (n = 26), 22 rats showed either bilateral or unilateral cryptorchidism at the age of 30 to 40 days old, and the occurrence of cryptorchidism was 84.6%. By contrast, the occurrence of cryptorchidism was 0% in the control rats (n = 15, P< .001). It is therefore suggested that prenatal exposure to MBP may disturb the Sertoli cells and elevate the fetal testes relative to thebladder neck while also inducing cryptorchidism postnatally. Sertoli cells may thus play an important role in the transabdominal descent ofthe testis by secreting Mullerian-inhibiting substance (MIS), which is known to act as a putative mediator of the transabdominal phase. Copyright (C) 1997 by W.B. Saunders Company

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:59:05