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Titolo: DOES CALCITONIN-GENE-RELATED PEPTIDE ACT AS A CHEMOATTRACTANT FOR RATGUBERNACULAR CELLS
Autore: SUGITA Y; PAXTON GA; HASTHORPE S; HUTSON JM;
- Indirizzi:
- ROYAL CHILDRENS HOSP,DEPT GEN SURG,FLEMINGTON RD PARKVILLE VIC 3052 AUSTRALIA ROYAL CHILDRENS HOSP,F DOUGLAS STEPHENS SURG RES LAB MELBOURNE VIC AUSTRALIA
- Titolo Testata:
- Journal of pediatric surgery
fascicolo: 1,
volume: 32,
anno: 1997,
pagine: 15 - 17
- SICI:
- 0022-3468(1997)32:1<15:DCPAAA>2.0.ZU;2-M
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- TESTICULAR DESCENT; GENITOFEMORAL NERVE; CRYPTORCHIDISM; CHEMOTAXIS; MIGRATION; SHOWS;
- Keywords:
- TESTICULAR DESCENT; CHEMOTAXIS; CALCITONIN GENE-RELATED PEPTIDE (CGRP); RAT GUBERNACULUM;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Science Citation Index Expanded
- Citazioni:
- 18
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- Y. Sugita et al., "DOES CALCITONIN-GENE-RELATED PEPTIDE ACT AS A CHEMOATTRACTANT FOR RATGUBERNACULAR CELLS", Journal of pediatric surgery, 32(1), 1997, pp. 15-17
Abstract
Calcitonin gene-related peptide (CGRP) receptors are located in the cremaster muscle of the gubernaculum of rats, and causes gubernacular contraction in vitro, suggesting that CGRP plays an important role in testicular descent. It has been postulated that CGRP released from the genitofemoral nerve acts as a ''chemoattractant'' for gubernacular migration to the scrotum. The aim of this study is td investigate whetherthe gubernacular cells of rats exhibit a chemotactic response to CGRPin vitro. Chemotaxis of gubernacular cells from Sprague-Dawley rats (1 to 6 days old) was measured using blind-well chambers. The migrationof cells, which passed from the upper to the lower compartment through a polycarbonate filter, were counted using microscopy. The lower compartment included 10(-11) 10(-10), 10(-9), and 10(-8) M CGRP or phosphate buffered saline (PBS) as control. The chemotactic index (CI) was defined as the ratio of migration toward CGRP Versus PBS as control. There was no significant migration even at varying CGRP concentrations. Isolated rat gubernacular cells therefore did not exhibit a chemotactic response to CGRP and the role CORP plays in testicular descent stillremains Unclear. This result does not exclude the possibility that the gubernaculum responds to CGRP as a whole organ rather than as individual cells. Copyright (C) 1997 by W.B. Saunders Company
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:48:35