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Titolo:
CEREBROSPINAL-FLUID NEURONAL THREAD PROTEIN COMES FROM SERUM BY PASSAGE OVER THE BLOOD-BRAIN-BARRIER
Autore:
BLENNOW K; WALLIN A; CHONG JK;
Indirizzi:
UNIV GOTHENBURG,DEPT CLIN NEUROSCI,PSYCHIAT & NEUROCHEM SECT S-43180 MOLNDAL SWEDEN ABBOTT LABS ABBOTT PK IL 60064
Titolo Testata:
Neurodegeneration
fascicolo: 2, volume: 4, anno: 1995,
pagine: 187 - 193
SICI:
1055-8330(1995)4:2<187:CNTPCF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC STONE PROTEIN; AMINO-ACID SEQUENCE; ALZHEIMERS-DISEASE; SECRETORY PROTEIN; CONCENTRATION GRADIENTS; VASCULAR DEMENTIA; EXPRESSION; ALBUMIN; JUICE;
Keywords:
ALZHEIMERS DISEASE (AD); BIOCHEMICAL MARKERS; BLOOD-BRAIN BARRIER (BBB); CEREBROSPINAL FLUID (CSF); NEURONAL THREAD PROTEIN (NTP); PANCREATIC THREAD PROTEIN (PTP);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
K. Blennow et al., "CEREBROSPINAL-FLUID NEURONAL THREAD PROTEIN COMES FROM SERUM BY PASSAGE OVER THE BLOOD-BRAIN-BARRIER", Neurodegeneration, 4(2), 1995, pp. 187-193

Abstract

Cerebrospinal fluid (CSF) biochemical markers for Alzheimer's disease(AD) would be of great value, both to improve clinical diagnostic accuracy and to increase our knowledge of the pathogenesis of the disorder. An increase in the CSF-level of 'neuronal thread protein' (pancreatic thread protein (PTP) immunoreactive material in the brain) has beensuggested to be just such a biochemical marker. We have studied CSF 'neuronal thread protein'-like immunoreactivity (NTPLI) using a microparticle enzyme immunoassay. CSF-NTPLI did not differ significantly between AD type I (pure AD) and controls, but was significantly higher in AD type II (senile dementia) and vascular dementia (VAD) as compared with controls. Signs of blood-brain barrier (BBB) damage (elevated CSF/S albumin ratio) were found in both AD type II and in VAD, but not in AD type I. In a multiple ANOVA, with age and CSF/S albumin ratio as covariates, no significant difference in CSF-NTPLI between diagnostic groups was noted though both CSF/S albumin ratio and age (P < 0.0001 andP < 0.001 respectively) were found to influence the CSF-NTPLI level. Since BBB function was found to influence the CSF-NTPLI level, we examined whether NTPLI was present in serum. Indeed, serum NTPLI was about40 times higher than CSF-NTPLI in neurological patients. Moreover, there was a statistically significant correlation between S-NTPLI and CSF-NTPLI. Taken together, present findings suggest that most of NTPLI in CSF comes from the serum, by passage over the BBB. As with the IgG index, we created a 'NTPLI index' (CSF/S NTPLI divided by CSF/S albuminratio) to evaluate if there was an increase in NTPLI locally producedwithin the CNS in AD. However, there were no significant differences in NTPLI index between any of the groups. These findings suggest that,using these antibodies, CSF-NTPLI has no potential as a biochemical marker for AD, and that it is important to consider confounding factors, such as BBB function, in CSF studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:04:32