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Titolo:
NONSTEROIDAL ANTIINFLAMMATORY DRUG MODULATION OF BEHAVIORAL-RESPONSESTO INTRATHECAL N-METHYL-D-ASPARTATE, BUT NOT TO SUBSTANCE-P AND AMINO-METHYL-ISOXAZOLE-PROPIONIC ACID IN THE RAT
Autore:
BJORKMAN R; HALLMAN KM; HEDNER J; HEDNER T; HENNING M;
Indirizzi:
GOTHENBURG UNIV,DEPT PHYSIOL & PHARMACOL,DIV CLIN PHARMACOL,MED AREGATAN 7 S-41390 GOTHENBURG SWEDEN SAHLGRENS UNIV HOSP S-41390 GOTHENBURG SWEDEN
Titolo Testata:
Journal of clinical pharmacology
fascicolo: 12, volume: 36, anno: 1996, supplemento:, S
pagine: 20 - 26
SICI:
0091-2700(1996)36:12<20:NADMOB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL SUBARACHNOID SPACE; NITRIC-OXIDE; CHRONIC CATHETERIZATION; MOUSE; CORD; DICLOFENAC; GLUTAMATE; ARGININE; NMDA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
R. Bjorkman et al., "NONSTEROIDAL ANTIINFLAMMATORY DRUG MODULATION OF BEHAVIORAL-RESPONSESTO INTRATHECAL N-METHYL-D-ASPARTATE, BUT NOT TO SUBSTANCE-P AND AMINO-METHYL-ISOXAZOLE-PROPIONIC ACID IN THE RAT", Journal of clinical pharmacology, 36(12), 1996, pp. 20-26

Abstract

Antinociception by nonsteroidal antiinflammatory drugs, notably diclofenac and S(+)-ibuprofen, has traditionally been attributed to peripheral tissue cyclooxygenase inhibition. This study investigates the potential role of the nitric oxide system for the central antinociceptive effects of diclofenac, S(+)-, and R(-)-ibuprofen. Diclofenac and S(+)-but not R(-)-ibuprofen inhibited the behavioral response dose dependently, ''biting, scratching, and licking (BSL),'' induced by the spinalapplication of N-methyl-D-aspartate, but not that of amino-methylisoxazole-propionic acid or substance P. Diclofenac and S(+)-ibuprofen induced a parallel shift in the number of BSL responses and in the duration of the response in the behavioral model at their approximate medianeffective doses (diclofenac 1 mu mol and S(+)-ibuprofen 5 mu mol). Pretreatment with L-arginine, the natural substrate for the nitric oxidesynthetase, antagonized diclofenac, and S(+)-ibuprofen-induced suppression of the biting, scratching, and licking response evoked by intrathecal N-methyl-D-aspartate. D-arginine did not antagonize the diclofenac- and S(+)-ibuprofen-induced antinociception. The study results indicate that analgesia after diclofenac and S(+)-ibuprofen involves a central mechanism which may add to the peripheral antinociceptive effect of these agents. The central action of diclofenac and S(+)-ibuprofen is partly mediated by on interaction with the N-methyl-D-aspartate receptor and nitric oxide-generating mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:09:42