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Titolo:
ALTERATIONS IN THE ACTION-POTENTIAL OF APLYSIA NEURONS EVOKED BY A PHORBOLESTER ARE MEDIATED BY PROTEIN-KINASE-C
Autore:
PAPP A; KLEE MR;
Indirizzi:
MAX PLANCK INST BRAIN RES,DEPT NEUROPHYSIOL,DEUTSCHORDENSTR 46 D-60528 FRANKFURT GERMANY MAX PLANCK INST BRAIN RES,DEPT NEUROPHYSIOL D-60528 FRANKFURT GERMANY
Titolo Testata:
Brain research
fascicolo: 1, volume: 684, anno: 1995,
pagine: 107 - 111
SICI:
0006-8993(1995)684:1<107:AITAOA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM CURRENT; SENSORY NEURONS; ACTIVATION; MODULATION; CHANNEL; ESTERS; ENHANCEMENT; INHIBITORS; CELLS; NA+;
Keywords:
APLYSIA; ACTION POTENTIAL; PROTEIN KINASE C; PHORBOL DIACETATE; H-7;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A. Papp e M.R. Klee, "ALTERATIONS IN THE ACTION-POTENTIAL OF APLYSIA NEURONS EVOKED BY A PHORBOLESTER ARE MEDIATED BY PROTEIN-KINASE-C", Brain research, 684(1), 1995, pp. 107-111

Abstract

Alterations in the parameters of action potentials upon changes in protein kinase C (PKC) activity were studied on neurons of the visceral ganglion of Aplysia californica. The amplitude and maximum speed of the up-and downstroke of the action potentials (APs) were measured. Intracellularly injected PKC and intra-and extracellularly applied phorbol-12,13-diacetate (PDAc) had similar effects on the Aplysia neurons, the most prominent being an increase of the upstroke speed of the AP in every neuron. The non-PKC-activating 4 alpha-phorbol didecanoate had no effect, and the effects of the PKC blocker H-7 were opposite to those of PDAc. It was concluded that the changes of the AP evoked by PDAc are mediated through PKC activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 03:05:09