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Titolo:
ALTERNATIVE SPLICING AND DIFFERENTIAL TARGETING OF FIBROBLAST GROWTH-FACTOR RECEPTOR-1 IN THE PREGNANT RAT UTERUS
Autore:
RIDER V; PIVA M; COHEN ME; CARLONE DL;
Indirizzi:
UNIV MISSOURI,SCH BIOL SCI,DEPT BIOCHEM & MOLEC BIOL KANSAS CITY MO 64110
Titolo Testata:
Endocrinology
fascicolo: 7, volume: 136, anno: 1995,
pagine: 3137 - 3145
SICI:
0013-7227(1995)136:7<3137:ASADTO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR PRODUCTION; NUCLEAR TRANSLOCATION SEQUENCE; FGF RECEPTOR; SIGNAL-TRANSDUCTION; TYROSINE KINASE; MESSENGER-RNA; DNA-SYNTHESIS; BASIC FGF; BINDING; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
V. Rider et al., "ALTERNATIVE SPLICING AND DIFFERENTIAL TARGETING OF FIBROBLAST GROWTH-FACTOR RECEPTOR-1 IN THE PREGNANT RAT UTERUS", Endocrinology, 136(7), 1995, pp. 3137-3145

Abstract

Recent studies suggest that steroid effects on uterine cell proliferation may be moderated by polypeptide growth factors. We now provide evidence that high affinity fibroblast growth factor (FGF) receptors arepresent temporally and spatially in the pregnant rat uterus (days 4-6)to support the idea that basic FGF action occurs via binding to its high affinity FGF receptor 1 (FGFR1). Reverse transcription-polymerase chain amplification indicates that both the full-length transcript andan alternatively spliced messenger RNA are present in the uterus. Western immunoblot analysis confirms that rat uterine membrane proteins contain two receptor isotorms, and these receptors bind basic FGF with high affinity and specificity. Immunolocalization of FGFR1 revealed receptor-positive cells in both the uterine stroma and epithelia on days4-6 of pregnancy. However, the receptor was differentially localized in the disparate cell types. The nuclei of stromal cells were positivefor FGFR1, whereas epithelial cell nuclei were negative. Together, these results suggest that FGF signal transduction in uterine stromal cells is mediated by activation of FGFR1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:48:05