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Titolo:
DOSIMETRY OF IODINE-123-EPIDEPRIDE - A DOPAMINE D2 RECEPTOR-LIGAND
Autore:
VOTAW JR; ANSARI MS; MASON NS; SCHMIDT D; DEPAULIS T; HOLBURN G; CLANTON JA; VOTAW DB; MANNING RG; KESSLER RM;
Indirizzi:
EMORY UNIV,DIV NUCL MED,1364 CLIFTON RD NE ATLANTA GA 30322 VANDERBILT UNIV,SCH MED,DEPT RADIOL NASHVILLE TN 37212 VANDERBILT UNIV,SCH MED,DEPT RADIOL SCI NASHVILLE TN 37212 VANDERBILT UNIV,SCH MED,DEPT PSYCHIAT NASHVILLE TN 37212 VANDERBILT UNIV,DEPT PHYS NASHVILLE TN 37212
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 7, volume: 36, anno: 1995,
pagine: 1316 - 1321
SICI:
0161-5505(1995)36:7<1316:DOI-AD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-AFFINITY; I-125 EPIDEPRIDE; RADIOLIGANDS; BRAIN;
Keywords:
IODINE-123-EPIDEPRIDE; DOSIMETRY; SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY; DOPAMINE D2 RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Votaw et al., "DOSIMETRY OF IODINE-123-EPIDEPRIDE - A DOPAMINE D2 RECEPTOR-LIGAND", The Journal of nuclear medicine, 36(7), 1995, pp. 1316-1321

Abstract

Substituted benzamides have been shown to have very high affinity andspecificity for the dopamine D2 receptor. One of these is radiolabeled epidepride, an iodine-substituted benzamide currently under evaluation as a SPECT imaging agent. Detailed estimates of the radiation absorbed dose to 26 organs and the whole body from [I-123]epidepride have been calculated. Methods: The dosimetry calculations use a combination of in vivo uptake and biodistribution data from one rhesus monkey and seven humans to estimate residence times in eight organs. The computerprogram MIRDOSE2 was used to calculate the dosimetry. Results: Results indicate that 75% of the radioactivity is cleared through the urinary tract while the remaining radioactivity clears through the gallbladder and intestinal tract. The radiation absorbed dose can be minimized by administering a high lipid content meal 1.5 hr postinjection to empty the gallbladder and by giving large volumes of fluids throughout the study to induce increased urinary output. Conclusion: By emptying the gallbladder and urinary bladder, the lower large intestine becomes the critical organ, 0.102 mGy/MBq (0.38 rad/mCi) followed by the upper large intestine, 0.092 mGy/MBq (0.34 rad/mCi). The effective dose equivalent is 0.025 mSv/MBq (0.092 rem/mCi).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 03:13:53