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Titolo:
A DIAGNOSTIC-APPROACH IN ALZHEIMERS-DISEASE USING 3-DIMENSIONAL STEREOTAXIC SURFACE PROJECTIONS OF FLUORINE-18-FDG PET
Autore:
MINOSHIMA S; FREY KA; KOEPPE RA; FOSTER NL; KUHL DE;
Indirizzi:
UNIV MICHIGAN HOSP,MED CTR,DEPT INTERNAL MED,DIV NUCL MED,1500 E MED CTR DR ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT INTERNAL MED,DIV NUCL MED ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT NEUROL ANN ARBOR MI 48109 UNIV MICHIGAN,DEPT RADIOL ANN ARBOR MI 48109
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 7, volume: 36, anno: 1995,
pagine: 1238 - 1248
SICI:
0161-5505(1995)36:7<1238:ADIAU3>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL GLUCOSE-METABOLISM; FUNCTIONAL BRAIN IMAGES; MULTI-INFARCT DEMENTIA; ADRDA WORK GROUP; COMPUTED-TOMOGRAPHY; CLINICAL-DIAGNOSIS; BLOOD-FLOW; ABNORMALITIES; LOCALIZATION;
Keywords:
ALZHEIMERS DISEASE; POSITRON EMISSION TOMOGRAPHY; GLUCOSE METABOLISM; IMAGE INTERPRETATION; BRAIN MAPPING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
S. Minoshima et al., "A DIAGNOSTIC-APPROACH IN ALZHEIMERS-DISEASE USING 3-DIMENSIONAL STEREOTAXIC SURFACE PROJECTIONS OF FLUORINE-18-FDG PET", The Journal of nuclear medicine, 36(7), 1995, pp. 1238-1248

Abstract

To improve the diagnostic performance of PET as an aid in evaluating patients suspected of having Alzheimer's disease, we developed a fullyautomated method which generates comprehensive image presentations and objective diagnostic indices. Methods: nuorine-18-fluorodeoxyglucosePET image sets were collected from 37 patients with probable Alzheimer's disease (including questionable and mild dementia), 22 normal subjects and 5 patients with cerebrovascular disease. Following stereotactic anatomic standardization, metabolic activity on an individual's PETimage set was extracted to a set of predefined surface pixels (three-dimensional stereotactic surface projection, 3D-SSP), which was used in the subsequent analysis. A normal database was created by averaging extracted datasets of the normal subjects. Patients' datasets were compared individually with the normal database by calculating a Z-score on a pixel-by-pixel basis and were displayed in 3D-SSP views for visualinspections. Diagnostic indices were then generated based on averagedZ-scores for the association cortices. Results: Patterns and severities of metabolic reduction in patients with probable Alzheimer's disease were seen in the standard 3D-SSP views of extracted raw data and statistical Z-scores. When discriminating patients with probable Alzheimer's disease from normal subjects, diagnostic indices of the parietal association cortex and unilaterally averaged parietai-temporal-frontal cortex showed sensitivities of 95% and 97%, respectively, with a specificity of 100%. Neither index yielded false-positive results for cerebrovascular disease. Conclusion: 3D-SSP enables quantitative data extraction and reliable localization of metabolic abnormalities by means ofstereotactic coordinates. The proposed method is a promising approachfor interpreting functional brain PEI scans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:21:59