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Titolo:
TECHNETIUM-99M-HMPAO SPECT IMAGING OF CEREBRAL BLOOD-FLOW DURING REM-SLEEP IN NARCOLEPTICS
Autore:
ASENBAUM S; ZEITLHOFER J; SALETU B; FREY R; BRUCKE T; PODREKA I; DEECKE L;
Indirizzi:
UNIV VIENNA,DEPT NEUROL,WAHRINGER GURTEL 18-20 A-1090 VIENNA AUSTRIA UNIV VIENNA,DEPT PSYCHIAT A-1090 VIENNA AUSTRIA
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 7, volume: 36, anno: 1995,
pagine: 1150 - 1155
SICI:
0161-5505(1995)36:7<1150:TSIOCB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
EYE-MOVEMENT SLEEP; POSITRON EMISSION TOMOGRAPHY; GLUCOSE-METABOLISM; HEMODYNAMICS;
Keywords:
RAPID-EYE-MOVEMENT SLEEP; NARCOLEPSY; REGIONAL CEREBRAL BLOOD FLOW; TECHNETIUM-99M-HMPAO; SINGLE-PHOTON EMISSION COMPUTERIZED TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S. Asenbaum et al., "TECHNETIUM-99M-HMPAO SPECT IMAGING OF CEREBRAL BLOOD-FLOW DURING REM-SLEEP IN NARCOLEPTICS", The Journal of nuclear medicine, 36(7), 1995, pp. 1150-1155

Abstract

This study was performed to demonstrate global and regional cerebral blood flow (rCBF) changes during rapid eye movement (REM) sleep in sixpatients with narcolepsy using SPECT and Tc-99m-HMPAO. Methods: Global and hemispheric HMPAO uptake as well as regional (RI) and asymmetry indices were estimated and compared between polysomnographically verified sleep onset (SO)REM and wakefulness. Results: The estimated globalHMPAO uptake did not differ between the two conditions indicating a similar overall cortical activity. During (SO)REM sleep, hemisphere HMPAO uptake as well as calculated RI, especially in the supratemporal plane, were significantly higher on the right side than contratateral. This indicates an initially right-sided cerebral activation and a special involvement of the right, nondominant hemisphere during dreaming which is responsible for visual-spatial perceptions. Furthermore, increased RI in superior parietal regions during sleep were evident and wereexplained by an activation of associative areas. In thalamic regions,decreased RI were found during sleep, which may reflect thalamic dysfunction. Conclusion: A definite assignment of these CBF alterations to(SO)REM sleep might be problematic because of unstable boundaries between sleep stages in narcolepsy. On the other hand, specificity of such CBF changes for narcolepsy requires further study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/10/19 alle ore 23:17:34