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Titolo:
CYTOKINE REGULATION OF ASTROCYTE FUNCTION - IN-VITRO STUDIES USING CELLS FROM THE HUMAN BRAIN
Autore:
ALOISI F; BORSELLINO G; CARE A; TESTA U; GALLO P; RUSSO G; PESCHLE C; LEVI G;
Indirizzi:
IST SUPER SANITA,DEPT ORGAN & SYST PATHOPHYSIOL,NEUROPHYSIOL UNIT,VIALE REGINA ELENA 299 I-00161 ROME ITALY IST SUPER SANITA,DEPT HEMATOL ONCOL I-00161 ROME ITALY UNIV PADUA,NEUROL CLIN PADUA ITALY HOSP AVELLINO,DIV OBSTET & GINECOL AVELLINO ITALY
Titolo Testata:
International journal of developmental neuroscience
fascicolo: 3-4, volume: 13, anno: 1995,
pagine: 265 - 274
SICI:
0736-5748(1995)13:3-4<265:CROAF->2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CENTRAL-NERVOUS-SYSTEM; COLONY-STIMULATING FACTORS; HUMAN-FETAL ASTROCYTES; INTERLEUKIN-1 RECEPTOR ANTAGONIST; ADHESION MOLECULE-1 ICAM-1; FACTOR-ALPHA; NEURONAL DIFFERENTIATION; INFLAMMATORY CYTOKINES; ANTIGEN PRESENTATION;
Keywords:
CYTOKINES; ASTROCYTES; INFLAMMATORY REACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
F. Aloisi et al., "CYTOKINE REGULATION OF ASTROCYTE FUNCTION - IN-VITRO STUDIES USING CELLS FROM THE HUMAN BRAIN", International journal of developmental neuroscience, 13(3-4), 1995, pp. 265-274

Abstract

Participation of astrocytes in central nervous system pathophysiologyis likely to involve cytokines, both as stimulators and mediators of astrocyte function. We have used highly enriched human astrocyte cultures as an experimental tool to investigate the influence of cytokines on adhesion molecule expression and synthesis of mediators that are probably important in immune and inflammatory reactions involving the nervous system and in cerebral tissue repair. The response of astrocytesto interferon-gamma mainly resulted in increased expression of major histocompatibility complex antigens and co-stimulatory molecules (intercellular adhesion molecule-1, LFA-1 alpha) which mediate astrocyte-T-cell interactions. Another co-stimulatory molecule, B7, was neither expressed nor inducible by IFN-gamma and other cytokines. TNF-alpha and IL-1 beta were more efficient in stimulating synthesis of immunoregulatory and proinflammatory cytokines (IL-6, IL-8 and colony-stimulating factors), cytokine antagonists (TNF-alpha soluble receptors), or cytokines with a possible neuroprotective role (leukemia inhibitory factor); they also increased expression of some co-stimulatory molecules (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1). Transforming growth factor-beta(1) was a strong inducer of leukemia inhibitory factor, but did not affect either major histocompatibilty complex/co-stimulatory molecule expression or cytokine synthesis. Thus, different cytokines activate distinct functional programs in astrocytes, which may play a specific role in different brain diseases or at different stages of the same disease. It was additionally observed that the response of human astrocytes to cytokines (in particular the inducible synthesis of certain cytokines) varied greatly depending on the presence or absence of neurons in the culture system. This finding suggests that neuronal-glial interactions may be implicated in determiningthe activation threshold of astrocytes to inflammatory cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:14:44