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Titolo:
INCREASED LEUKOCYTE ADHESIVENESS AGGREGATION IS A MOST USEFUL INDICATOR OF DISEASE-ACTIVITY IN PATIENTS WITH INFLAMMATORY BOWEL-DISEASE/
Autore:
ARBER N; BERLINER S; HALLAK A; BUJANOVER Y; DOTAN I; LIBERMAN E; SANTO M; MOSHKOWITZ M; RATAN J; DOTAN G; KONIKOFF FM; ARONSON M; GILAT T;
Indirizzi:
ICHILOV HOSP,TEL AVIV MED CTR,DEPT GASTROENTEROL,6 WEIZMAN ST IL-64239 TEL AVIV ISRAEL ICHILOV HOSP,TEL AVIV MED CTR,DEPT GASTROENTEROL IL-64239 TEL AVIV ISRAEL TEL AVIV UNIV,SACKLER FAC MED,BASIL & GERALD FELSENSTEIN LAB INFLAMMAT TEL AVIV ISRAEL TEL AVIV UNIV,SACKLER FAC MED,DEPT CELL BIOL TEL AVIV ISRAEL
Titolo Testata:
Gut
fascicolo: 1, volume: 37, anno: 1995,
pagine: 77 - 80
SICI:
0017-5749(1995)37:1<77:ILAAIA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-REACTIVE PROTEIN; MYOCARDIAL REPERFUSION INJURY; CROHNS-DISEASE; ULCERATIVE-COLITIS; PERIPHERAL-BLOOD; LEUKOCYTE AGGREGATION; MONOCLONAL-ANTIBODY; CLINICAL ACTIVITY; ACTIVITY INDEX; LEUKERGY TEST;
Keywords:
DISEASE ACTIVITY; INFLAMMATORY BOWEL DISEASE; LEUKOCYTE ADHESIVENESS AGGREGATION TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
N. Arber et al., "INCREASED LEUKOCYTE ADHESIVENESS AGGREGATION IS A MOST USEFUL INDICATOR OF DISEASE-ACTIVITY IN PATIENTS WITH INFLAMMATORY BOWEL-DISEASE/", Gut, 37(1), 1995, pp. 77-80

Abstract

The aim of the study was to determine the comparative usefulness of inflammatory markers, in evaluating disease activity in patients with inflammatory bowel disease. Disease activity was assessed by the Mayo Clinic score for ulcerative colitis, and Harvey-Bradshaw score for Crohn's disease. Five hundred normal blood donors who had no underlying inflammatory condition served as controls. The erythrocyte sedimentationrate, platelet and white blood cell count, C reactive protein, and the leucocyte adhesiveness/aggregation test (LAAT) were determined in each patient. One hundred and twenty four patients with inflammatory bowel disease were tested while in remission and 128 in relapse. Their mean (SD) per cent of aggregated white blood cells in the peripheral blood was 8 (5) and 17 (10) respectively compared with controls 6 (4) (p < 0.0001). Moreover, the LAAT could effectively discriminate between various grades of disease activity, the values in patients with active disease being 13 (6)% in mild, 17 (10)% in moderate, and 26 (10)% in severe disease (p < 0.0001). Other acute phase reactants including the erythrocyte sedimentation rate, the white blood cell count, the platelet count, neutrophil count, as well as, the C reactive protein concentration did not differentiate as well between the various groups. Usinglogistic regression analysis to differentiate between inflammatory bowel disease patients in remission or relapse, the LAAT was the single best indicator. The addition of any other test did not contribute to the discrimination. Among the different laboratory variables tested only between the five different subgroups of controls, remission and mild, moderate or severe disease activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:59:50