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Titolo:
EFFECT OF LATERAL HYPOTHALAMUS LESIONS ON THE WATER AND SALT INTAKE, AND SODIUM AND URINE EXCRETION INDUCED BY ACTIVATION OF THE MEDIAN PREOPTIC NUCLEUS IN CONSCIOUS RATS
Autore:
DASILVA RKP; SAAD WA; RENZI A; MENANI JV; CAMARGO LAD;
Indirizzi:
PAULISTA STATE UNIV,SCH DENT,DEPT PATHOL BR-14801903 ARARAQUARA SP BRAZIL PAULISTA STATE UNIV,SCH DENT,DEPT PATHOL BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 2-3, volume: 53, anno: 1995,
pagine: 195 - 204
SICI:
0165-1838(1995)53:2-3<195:EOLHLO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
3RD VENTRICLE AV3V; ANGIOTENSIN-II; PRESSOR-RESPONSES; SUBFORNICAL ORGAN; PERIVENTRICULAR TISSUE; NATRIURETIC RESPONSES; DRINKING RESPONSE; VASOPRESSIN; PATHWAYS; AREA;
Keywords:
INGESTION; EXCRETION; ANGIOTENSIN II; CARBACHOL; NORADRENALINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
R.K.P. Dasilva et al., "EFFECT OF LATERAL HYPOTHALAMUS LESIONS ON THE WATER AND SALT INTAKE, AND SODIUM AND URINE EXCRETION INDUCED BY ACTIVATION OF THE MEDIAN PREOPTIC NUCLEUS IN CONSCIOUS RATS", Journal of the autonomic nervous system, 53(2-3), 1995, pp. 195-204

Abstract

In this-study we investigated the influence of electrolytic lesion ofthe lateral hypothalamus (LH) on the water and salt appetite, and thenatriuretic, diuretic and cardiovascular effects induced by angiotensinergic, cholinergic and noradrenergic stimulation of the median preoptic nucleus (MnPO) in rats. Male Holtzman rats were implanted with a cannula into the MnPO. Other groups of sham- and LH-lesioned rats received a stainless steel cannula implanted into the MnPO. ANGII injectioninto the MnPO induced water and sodium intake, and natriuretic, diuretic, presser and tachycardic responses. Carbachol induced water intake, and natriuretic, presser and bradycardic responses, whereas noradrenaline increased urine, sodium excretion and blood pressure, and induced bradycardia. In rats submitted to LH-lesion only, water and sodium intake was reduced compared with sham rats. LH lesion also reduced the sodium ingestion induced by ANGII (12 ng) into the MnPO. In LH-lesioned rats, the dipsogenic, diuretic and presser responses induced by ANGII (12 ng), carbachol (2 nmol) and noradrenaline (20 nmol) injection into the MnPO were reduced. The same occurred with sodium excretion whencarbachol (2 nmol) and noradrenaline (20 nmol) were injected into theMnPO of LH-lesioned rats, whereas ANGII(12 ng) induced an increase insodium excretion. These data show that electrolytic lesion of the LH reduces fluid and sodium intake, and presser responses to angiotensinergic, cholinergic and noradrenergic activation of the MnPO. LH involvement with MnPO excitatory and inhibitory mechanisms related to water and sodium intake, sodium excretion and cardiovascular control is suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:00:22