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Titolo:
EVIDENCE FOR AFFERENT FIBER INNERVATION OF PARASYMPATHETIC NEURONS OFTHE GUINEA-PIG CARDIAC GANGLION
Autore:
HARDWICK JC; MAWE GM; PARSONS RL;
Indirizzi:
UNIV VERMONT,DEPT ANAT & NEUROBIOL,GIVEN BLDG BURLINGTON VT 05405
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 2-3, volume: 53, anno: 1995,
pagine: 166 - 174
SICI:
0165-1838(1995)53:2-3<166:EFAFIO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; SUBSTANCE-P; ELECTROPHYSIOLOGICAL PROPERTIES; SENSORY NEURONS; NERVE-FIBERS; TACHYKININS; CAPSAICIN; HEART; RAT; IMMUNOREACTIVITY;
Keywords:
TACHYKININ; SUBSTANCE P; NEUROKININ A; NEUROKININ B; CAPSAICIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Hardwick et al., "EVIDENCE FOR AFFERENT FIBER INNERVATION OF PARASYMPATHETIC NEURONS OFTHE GUINEA-PIG CARDIAC GANGLION", Journal of the autonomic nervous system, 53(2-3), 1995, pp. 166-174

Abstract

The present study was done to establish whether peptidergic afferent inputs can modulate parasympathetic neurons of the guinea-pig cardiac ganglion. Whole mount preparations from the guinea-pig heart were utilized to localize afferent terminals by immunohistochemistry and for intracellular recordings from individual neurons in situ. Action potentials could be elicited by both intracellular current injection and stimulation of interganglionic fiber bundles. Two types of neuron, phasic (95%) and tonic (5%) as defined by their firing properties, were observed. High frequency (5-10 Hz) interganglionic fiber stimulation produced a calcium-dependent, slow depolarization in many cells which was not blocked by 100 mu M hexamethonium or 1 mu M atropine. A prolonged depolarization was also produced by local application of capsaicin (1 mM), which releases substance P and CGRP from afferent nerve terminals. Microejection of the mammalian tachykinins substance P, neurokinin A and neurokinin B (all at 100 mu M), also produced a slow depolarization. Application of specific agonists for the tachykinin receptor subtypes indicated that these neurons express both NK2 and NK3 receptors. Individual cells were filled with neurobiotin to examine their morphologyand the preparations were counter-stained for SP-like immunoreactivity. The results demonstrated that SP-positive fibers are found in closeapposition to both phasic and tonic neurons. From these results, we suggest that the parasympathetic neurons of the guinea-pig cardiac ganglion receive inputs from peptidergic, afferent fibers and that this input provides a pathway for potential local reflex control of cardiac function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:46:59