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Titolo:
CHORIONIC VILLUS SAMPLING BY BIOPSY FORCEPS - RESULTS OF 1580 PROCEDURES FROM A SINGLE CENTER
Autore:
FORTUNY A; BORRELL A; SOLER A; COSTA D; CARRIO A; PUERTO B; SERIES A; CARARACH J; DELGADO R;
Indirizzi:
UNIV BARCELONA,SCH MED,HOSP CLIN,DEPT OBSTET & GYNECOL,REPROD COUNSELLING & PRENAT DIAG UNIT E-08036 BARCELONA SPAIN
Titolo Testata:
Prenatal diagnosis
fascicolo: 6, volume: 15, anno: 1995,
pagine: 541 - 550
SICI:
0197-3851(1995)15:6<541:CVSBBF>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CLINICAL-TRIAL; EARLY PRENATAL-DIAGNOSIS; 1ST TRIMESTER; EARLY-PREGNANCY; FOLLOW-UP; AMNIOCENTESIS; GESTATIONS; EFFICACY; RISK; CVS;
Keywords:
CHORIONIC VILLUS SAMPLING; BIOPSY FORCEPS; MATERNAL SERUM ALPHA-FETOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
A. Fortuny et al., "CHORIONIC VILLUS SAMPLING BY BIOPSY FORCEPS - RESULTS OF 1580 PROCEDURES FROM A SINGLE CENTER", Prenatal diagnosis, 15(6), 1995, pp. 541-550

Abstract

The results of a prospective series of 1580 chorionic villus sampling(CVS) procedures using biopsy forceps are presented. Most of the procedures (1442), including 11 sets of twins, were performed by the transcervical approach (TC-CVS), using a curved-shank thin forceps, and 138by the transabdominal approach (TA-CVS), using a trocar-guided straight thin forceps. The mean gestational age for TC-CVS was 10.9 weeks, and in 233 cases (16 per cent) the procedure was carried out between the 12th and 14th weeks. The mean gestational age for TA-CVS was 16.7 weeks. The major indication for CVS was advanced maternal age (92.7 per cent in the TC and 91.8 per cent in the TA approach), and indications for abnormal ultrasound findings were more common in the TA approach (4.5 per cent) than in TC-CVS (0.07 per cent). Although sampling was apparently accomplished in all the procedures, in 3.1 per cent of the TC-CVS and 2.2 per cent of TA-CVS procedures, the samples were less than1 mg after dissection. A cytogenic report was obtained in 96.1 per cent of the TC-CVS and 90.6 per cent of the TA-CVS. Maternal serum alpha-fetoprotein (MSAFP) was measured before and after TC-CVS and the post-CVS MSAFP was positively correlated with the sample weight. Second-trimester amniocentesis following CVS was required in 5.2 per cent (TC-CVS) and 6.5 per cent (TA-CVS), due to the failure to obtain a cytogenetic report or diagnostic confirmation. The follow-up to the 20th week was 100 per cent by ultrasound scan, and 88.6 per cent from the 21st week to 1 week after delivery. Fetal loss rates within 2 weeks of the procedure were 1.7 per cent (TC-CVS) and 0.8 per cent (TA-CVS) and total fetal loss accumulated to 1 week after delivery was 4.6 per cent (TC-CVS) and 5.9 per cent (TA-CVS). Factors found to increase significantly fetal loss in the TC-CVS series were maternal age and the collection of very small samples, but not the number of forceps insertions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:12:13