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Titolo:
INFLUENCE OF ROUTE OF ADMINISTRATION ON [H-3] CAMPTOTHECIN DISTRIBUTION AND TUMOR UPTAKE IN CASE BEARING NUDE-MICE - WHOLE-BODY AUTORADIOGRAGHIC STUDIES
Autore:
AHMED AE; JACOB S; GIOVANELLA BC; KOZIELSKI AJ; STEHLIN JS; LIEHR JG;
Indirizzi:
UNIV TEXAS,MED BRANCH,DEPT PATHOL GALVESTON TX 77555 UNIV TEXAS,MED BRANCH,CTR CANC GALVESTON TX 77555 STEHLIN FDN CANC RES HOUSTON TX 77002 UNIV TEXAS,DEPT PHARMACOL & TOXICOL GALVESTON TX 77555
Titolo Testata:
Cancer chemotherapy and pharmacology
fascicolo: 1-2, volume: 39, anno: 1996,
pagine: 122 - 130
SICI:
0344-5704(1996)39:1-2<122:IOROAO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBOXYLATE FORMS; CANCER; CHEMOTHERAPY; DISPOSITION; XENOGRAFTS; NSC-100880; COMPONENTS; MECHANISM; TOXICITY; LACTONE;
Keywords:
CAMPTOTHECIN; WHOLE-BODY AUTORADIOGRAPHY; TUMOR UPTAKE; CASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
A.E. Ahmed et al., "INFLUENCE OF ROUTE OF ADMINISTRATION ON [H-3] CAMPTOTHECIN DISTRIBUTION AND TUMOR UPTAKE IN CASE BEARING NUDE-MICE - WHOLE-BODY AUTORADIOGRAGHIC STUDIES", Cancer chemotherapy and pharmacology, 39(1-2), 1996, pp. 122-130

Abstract

Camptothecin (CPT) inhibits the growth of a wide variety of experimental tumors. As a part of our exploration of this drug for use as a cancer chemotherapeutic agent, we studied the effect of route of administration on the absorption, distribution and tumor uptake of [H-3]-CPT. The rate of disappearance of [H-3]-CPT-derived radioactivity from blood during the first 48 h was highest following oral than following intravenous (i.v.) administration. Thereafter blood levels were low irrespective of route of administration. Considerable [H-3]-CPT-derived radioactivity was detected in urine and feces up to 48 h after dosing Distribution studies were conducted using quantitative whole-body autoradiography (WBA). These studies revealed that independent of the route ofadministration, [H-3]-CPT was rapidly excreted in the bile (gallbladder) followed by elimination into the small and large intestinal tract. Levels of CPT-derived radioactivity in the kidneys were minimal and mostly localized in the renal pelvis. Hepatic concentrations of CPT were low and were almost equal to those of the tumor. The lungs of animals treated i.v. showed higher uptake of radioactivity than those treated intramuscularly or orally. Tumor/blood ratios were slightly higher following oral administration than following administration by other routes. This study indicates that CPT is primarily eliminated via the bile. The gastrointestinal tract is the major site of accumulation and excretion of CPT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 16:08:48