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Titolo:
THE ANTITUMOR-ACTIVITY OF THE DNA FRACTION FROM MYCOBACTERIUM-BOVIS BCG (MY-1) FOR GLIOBLASTOMA
Autore:
NAKAICHI M; TAKEUCHI A; SHITARA N; TAKAKURA K;
Indirizzi:
YAMAGUCHI UNIV,DEPT VET SURG YAMAGUCHI 753 JAPAN YAMAGUCHI UNIV,DEPT VET HOSP YAMAGUCHI 753 JAPAN TOKYO METROPOLITAN KOMAGOME HOSP,BUNKYO KU TOKYO 113 JAPAN TOKYO WOMENS MED COLL,SHINJUKU KU TOKYO 162 JAPAN
Titolo Testata:
Journal of veterinary medical science
fascicolo: 3, volume: 57, anno: 1995,
pagine: 583 - 585
SICI:
0916-7250(1995)57:3<583:TAOTDF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEOXYRIBONUCLEIC-ACID FRACTION; KILLER CELL-ACTIVITY; AUGMENTATION;
Keywords:
GLIOBLASTOMA; IMMUNOTHERAPY; MY-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
M. Nakaichi et al., "THE ANTITUMOR-ACTIVITY OF THE DNA FRACTION FROM MYCOBACTERIUM-BOVIS BCG (MY-1) FOR GLIOBLASTOMA", Journal of veterinary medical science, 57(3), 1995, pp. 583-585

Abstract

The antitumor activity of the DNA fraction extracted from Mycobacterium bovis BCG (MY-1) for glioblastoma was investigated in the experimentally produced brain tumor in rats. The tumor-bearing rats were given intralesional injection of 1 mg of MY-1 twice a week for three weeks, and were sacrificed for comparison with those of control rats. The main macroscopic features of the tumors treated with serial injections ofMY 1 were cystic and destructive structures, which were histologically characterized by multiple microcysts containing macrophages. Furthermore, infiltration of leukocytes as well as the perivascular cuffing in the marginal area was observed. These findings suggested that the serial injections of MY-1 into the brain tumor have the therapeutic potential for glioblastoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:19:21