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Titolo:
EFFECTS OF SINGLE AND REPEATED ORAL-ADMINISTRATION OF FLUVOXAMINE ON EXTRACELLULAR SEROTONIN IN THE MEDIAN RAPHE NUCLEUS AND DORSAL HIPPOCAMPUS OF THE RAT
Autore:
BOSKER FJ; KLOMPMAKERS AA; WESTENBERG HGM;
Indirizzi:
UNIV UTRECHT,RUDOLF MAGNUS INST NEUROSCI,DEPT PSYCHIAT UTRECHT NETHERLANDS
Titolo Testata:
Neuropharmacology
fascicolo: 5, volume: 34, anno: 1995,
pagine: 501 - 508
SICI:
0028-3908(1995)34:5<501:EOSARO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL-CORTEX; RELEASE INVIVO; BRAIN; MICRODIALYSIS; AGONISTS; 5-HYDROXYTRYPTAMINE; TRANSPORTER; CITALOPRAM; 8-OH-DPAT; INCREASE;
Keywords:
MICRODIALYSIS; MEDIAN RAPHE NUCLEUS; HIPPOCAMPUS; FLUVOXAMINE; RU 24969; 5-HT; SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
F.J. Bosker et al., "EFFECTS OF SINGLE AND REPEATED ORAL-ADMINISTRATION OF FLUVOXAMINE ON EXTRACELLULAR SEROTONIN IN THE MEDIAN RAPHE NUCLEUS AND DORSAL HIPPOCAMPUS OF THE RAT", Neuropharmacology, 34(5), 1995, pp. 501-508

Abstract

The delay in clinical effects of selective serotonin reuptake inhibitors (SSRIs) suggest the existence of adaptive phenomena, such as receptor sensitivity changes. To examine the effects of repeated administration of SSRIs on serotonin neurotransmission, we investigated the effects of acute and chronic administration of the SSRI fluvoxamine on theextracellular levels of 5-HT in the median raphe nucleus and dorsal hippocampus of conscious rats by means of brain microdialysis. A singleoral dose of fluvoxamine (30 mg/kg) augmented extracellular 5-HT in the median raphe and dorsal hippocampus to 270 and 191 % of baseline level, respectively. Administration of fluvoxamine (30 mg/kg) or vehiclefor 14 days did not affect 5-HT baseline levels. Moreover, the increase in extracellular 5-HT in the median raphe nucleus and dorsal hippocampus after an oral dose of fluvoxamine (30 mg/kg) in rats chronicallytreated with fluvoxamine was not different from rats treated with vehicle. Using RU 24969 as a probe for the sensitivity of the 5-HT1B autoreceptors in the dorsal hippocampus, no change in receptor sensitivitycould be observed. These results demonstrate that repeated oral treatment with fluvoxamine does not affect extracellular 5-HT in the medianraphe and dorsal hippocampus, suggesting that presynaptic functional changes of 5-HT in the brain areas tested are not implicated in the observed delayed onset of action of this SSRI in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:36:54