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Titolo:
EFFECT OF ESSENTIAL FATTY-ACID DEFICIENCY ON MEMBRANE FATTY-ACID CONTENT AND GROWTH-HORMONE STIMULATION OF RAT PITUITARIES DURING POSTNATAL-DEVELOPMENT
Autore:
SOARES MC; ALESSIO ML; LEGER CL; BLUETPAJOT MT; CLAUSER H; ENJALBERT A; KORDON C; WANDSCHEER DE;
Indirizzi:
CTR PAUL BROCA,INSERM,U159,2 RUE DALESIA F-75014 PARIS FRANCE CTR PAUL BROCA,INSERM,U159 F-75014 PARIS FRANCE UNIV FED PERNAMBUCO,DEPT FISIOL & FARMACOL RECIFE PE BRAZIL INSERM,U58 F-34090 MONTPELLIER FRANCE
Titolo Testata:
Journal of lipid research
fascicolo: 6, volume: 36, anno: 1995,
pagine: 1401 - 1406
SICI:
0022-2275(1995)36:6<1401:EOEFDO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; LINOLEIC-ACID; EICOSAPENTAENOIC ACID; SIGNAL TRANSDUCTION; LIPID-COMPOSITION; ARACHIDONATE; BRAIN; PHOSPHOLIPASE-A2; DESATURATION; CHOLESTEROL;
Keywords:
ARACHIDONIC ACID; ESSENTIAL FATTY ACIDS; PHOSPHOLIPIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Soares et al., "EFFECT OF ESSENTIAL FATTY-ACID DEFICIENCY ON MEMBRANE FATTY-ACID CONTENT AND GROWTH-HORMONE STIMULATION OF RAT PITUITARIES DURING POSTNATAL-DEVELOPMENT", Journal of lipid research, 36(6), 1995, pp. 1401-1406

Abstract

Fatty acid composition of anterior pituitary cell membranes of rats deprived of essential fatty acids (EFA) and of rats receiving a standard diet was determined during postnatal development and in adults. Pregnant rats were fed an EFA-deficient diet and the offspring were fed the same diet after weaning. In parallel, effects of the diet on growth and on growth hormone (GH) responsiveness to GHRH stimulation were determined in control animals. Membrane content of arachidonic acid (20:4n-6) and of its elongation product adrenic acid (22:4n-6) increased regularly from day 2 to day 12 after birth. EFA-deficiency resulted on day 2 in increased oleic acid and in substitution of arachidonic and adrenic acids by corresponding elongation-desaturation products of oleicacid: eicosatrienoic (20:3n-9) and docosatrienoic (22:3n-9) acids. Atthe age of 24 days, n-9 series fatty acid reached the same level as in adult animals. Two-day-old EFA-deficient rats paradoxically exhibited a higher level of 20:4n-6 as compared to control rats. EFA-deficiency also decreased growth rate and GH pituitary responses to GHRH duringthe prepubertal period. These results suggest that changes in the lipid structure and in pituitary secretion properties elicited by EFA-deficiency depend upon the stage of development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:51:01